Comparison of Gastroesophageal Reflux and Quality of Life Between Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer Patients

Qilu Hospital of Shandong University1 个研究点分布在 1 个国家目标入组 52 人开始时间: 2026年5月1日最近更新: 2026年6月9日

试验速览

阶段: 不适用
状态: 招募中
发起方: Qilu Hospital of Shandong University
入组人数: 52
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA). Participants were divided into two groups based on the surgical procedure. We conducted a comparative analysis of postoperative outcomes by evaluating electronic medical records, postoperative gastroscopy, 24-hour esophageal pH monitoring, and relevant rating scales.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Prevention
盲法: None

入排标准

年龄范围: 18 Years 至 75 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Pathologically confirmed gastric adenocarcinoma by biopsy
•Carcinoma of the upper gastric body or Siewert type II/III adenocarcinoma of the esophagogastric junction (AEG), with a clinical stage of cT1-3N0-1M0
•Age 18-75 years, with a performance status (PS) score of 0-2
•Candidates for planned surgical resection, eligible for either double-tract reconstruction or tubular gastric anastomosis based on preoperative assessment
•No severe dysfunction of vital organs (liver, kidney, heart, lung, or brain), and no severe infection or uncontrolled chronic diseases

排除标准

•Presence of other malignant tumors or severe chronic diseases (e.g., severe diabetes mellitus, chronic kidney disease, decompensated cirrhosis, etc.)
•Preoperative endoscopic diagnosis of Barrett's esophagus
•Severe preoperative malnutrition (albumin <30 g/L, prealbumin <150 mg/L)
•History of prior upper abdominal surgery, gastrointestinal malformation, or psychiatric disorders
•Preoperative diagnosis of obstructive motor disorders of the cardia (including achalasia spectrum disorders)
•Inability to cooperate with or complete the required postoperative examinations

研究者

发起方

Qilu Hospital of Shandong University

申办方类型

Other

责任方

Sponsor

研究点 (1)

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