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临床试验/NCT03370081
NCT03370081已完成不适用

Effects of Capnometry Monitoring in Post Anesthesia Care Unit

University Hospital, Bordeaux1 个研究点 分布在 1 个国家目标入组 53 人开始时间: 2018年1月15日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
53
试验地点
1
主要终点
End Tidal CO2 up

研究概览

简要总结

There is few information about the best capnometry value in recovery room for intubated awakening patients. Furthermore, capnometry values could influence ventilation applied by nurses on these patients. The aim of this study is to observe the effects of capnometry monitoring on intubated awakening patients in recovery room.

详细描述

In France, there is actually no recommandation about capnography monitoring in recovery rooms. Nevertheless, some patients are still ventilated in post-anesthesia care units during awakening period. Alveolar hypoventilation could induce moderate hypercapnia, thereby stimulate central ventilatory command. However, this hypoventilation could delay the clearance of anesthetic gases. Capnometry monitoring could influence ventilation applied to these patients. Recovery rooms nurses would perform moderate hyperventilation in response to hign capnometry values. This method could enhance gases elimination, with faster spontaneous breathing recovery and extubation. Length of stay in recovery room could also be shortened. An objective surrogate of ventilation is maximal End Tidal CO2, if there is no alveolo-capillary gradient abnormality (Obesity, Chronic respiratory disease, Cyanogenic heart disease). Thus, this study will compare the percentage of patients who reached a maximum End Tidal CO2 greater than 45mmHg during awakening period in post-anesthesia care unit (PACU) in 2 groups :

  • first group ("non-blind group") with capnography monitoring see by the PACU nurses
  • second group ("blind group") with capnography monitoring but PACU nurses cannot see the values Other parameters like the time between ventilator's disconnection and the first ventilatory cycle in spontaneous ventilation, the time between ventilator's disconnection and tracheal extubation or laryngeal mask's withdrawal, the minimal SpO2 reached after tracheal extubation or laryngeal mask withdrawal or the length of stay in PACU are also recorded.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Major patients with given written consent
  • •General anesthesia, induction with Propofol infusion and Target-Controlled Infusion (TCI) remifentanil, relayed with inhaled sevoflurane and TCI remifentanil
  • •Upper airway control with naso-orotracheal tube or laryngeal mask
  • •Ventilated normotherm patients in PACU

排除标准

  • •Minor or pregnant patients
  • •Obesity with Body Mass Index > 40 kg/m²
  • •Chronic respiratory disease with SpO2<90% in ambiant air
  • •Cyanogenic heart disease
  • •Patients under myorelaxant in PACU

研究组 & 干预措施

CAPNO+

Experimental

END TIDAL CO2(EtCO2) is monitoring and PACU nurses can see the values delivered by the capnography device

干预措施: CAPNOGRAPHY (Device)

CAPNO-

No Intervention

END TIDAL CO2(EtCO2) is monitoring but PACU nurses cannot see the values delivered by the capnography device

结局指标

主要结局

End Tidal CO2 up

时间窗: through awakening period in PACU, an average of 30 minutes

Percentage of patients who reached a maximum End Tidal CO2 greater than 45mmHg during awakening period in post-anesthesia care unit (PACU)

次要结局

  • length of stay in PACU(through awakening period in PACU, an average of 2 hours)
  • End Tidal CO2 max 2(through awakening period in PACU, an average of 30 minutes)
  • spontaneous ventilation time(through awakening period in PACU, an average of 15 minutes)
  • time for removal of airway device(through awakening period in PACU, an average of 30 minutes)
  • Spo2 min(through awakening period in PACU, an average of 2 hours)
  • End Tidal CO2 max 1(through awakening period in PACU, an average of 15 minutes)
  • respiratory rate(through awakening period in PACU, an average of 15 minutes)
  • time for oxygenotherapy removal(through awakening period in PACU, an average of 1 hour)

研究者

发起方
University Hospital, Bordeaux
申办方类型
Other
责任方
Principal Investigator
主要研究者

Karine Nouette-Gaulain

M.D; PH.D. Head of department, Anesthesiology and ICU, clinical professor

University Hospital, Bordeaux

研究点 (1)

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