is Generalized Aggressive Periodontitis an Endless Disease When Does it Stop
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- the radiographic eruption date of the first and the last affected teeth
研究概览
简要总结
Background: Inquiring thoroughly and systematically for evidence supporting the mechanism, time span, onset, or ending events of generalized aggressive periodontitis. The aim of the current retrospective cross-sectional study was to set temporal boundaries of the generalized form of aggressive periodontitis based on eruption time of permanent teeth via panoramic radiographs.
Methods: based on the Egyptian chronology, the primary outcome of the current retrospective study was to assess the correlation between the eruption sequence and the temporal borders of the disease as well as the prevalence of destructive events in accordance to the eruption schedule. The first affected tooth, the last affected tooth, the first unaffected tooth, the number of affected teeth, the presence of interrupted tooth all are factors that extracted from the panoramic radiographs.
详细描述
During the last decades, progressive lines of thinking were proposed by generations of brilliant periodontists who tried to describe the aggressive destruction of periodontal tissues. Periodontitis was basically described 2000 years ago but in 18th century, signs and symptoms of periodontitis were firstly recorded.
History of aggressive periodontitis At the beginning of 19th century, alveolar pyorrhea was a term created and explained by two different schools; the European school has described it as a disease which is not affected by local factors while the American school has described local factors especially salivary calculus as the main cause behind alveolar pyorrhea.
Later by the development of histological, radio graphical and microbiological analysis, three other explanation were raised; school of atrophy and degeneration, school of occlusal trauma and school of infection. The European School has supported the theory of atrophy and degeneration especially in young individuals. Their explanation was mainly based on the histological studies which concluded that alveolar bone loss is the primary crucial point in periodontal disease preceded by gingival ulceration and inflammation. Pocket formation and epithelial proliferation are secondary events. Furthermore, they also reported that inflammation and suppuration are strongly connected to the presence of external irritation and entitled it ''Diffuse atrophy''.
Classification of Aggressive periodontitis In 80s and 90s, numerous classifications with various staging and subtypes had been conducted which were not based upon the true diagnostic background. In 1986, the American academy of periodontology acknowledged the exclusion of rapidly progressive periodontitis and added prepubertal periodontitis as a subclass to juvenile periodontitis. In 1989, the American academy classification was modified. They proposed early onset periodontitis to include both prepubertal, juvenile and rapidly progressive periodontitis and added periodontitis associated with systemic disease as separate entity. In 1989, Topic subdivided the periodontal conditions into acute and chronic. The acute condition included periodontal abscess, pericoronitis while the chronic condition included periodontitis (simplex, complex and generalized forms), localized forms (juvenile, post-juvenile and prepubertal) and symptomatic. The latter classification was lacking essential details concerning the periodontal diseases. In 1994, the European Workshop on Periodontology condensed the previous classes into; early onset, adult and necrotizing periodontitis. In 1997, the Committee of American Academy of Periodontology had set a plan to revise the previously proposed classifications.
Sub-typing of aggressive periodontitis Early onset description of periodontitis was mainly based on the influence of patient's age at the time of reporting the evolution of symptoms added to the short-term period in which uppermost destructive events had happened. In 1989 classification, early onset periodontitis was sub-categorized as pre-pubertal juvenile and rapidly progressive periodontitis. Both sub-categories approved to be either localized or generalized.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with generalized ggressive perioodntitis only
- •Panoramic view is a must
- •Patient age ≥ 18 years
- •both genders were enrolled
- •Radiographic evidence of bony defects was compulsory for inclusion.
排除标准
- •patients who did not have panoramic radiograph in their files
- •Patients less than 18 years are not included
结局指标
主要结局
the radiographic eruption date of the first and the last affected teeth
时间窗: 4 years
based on panoramic view of each patient, the radiographic eruption date of the mentioned teeth was determined.
次要结局
- The radiographic status of the supporting structures of third molars(4 years)
研究者
Rasha Wagih
Head of periodontology department
Badr University
