Puerarin (NPI-031G) Effects on Alcohol Drinking - A Natural Settings Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Amount of Alcohol Consumed
研究概览
简要总结
This research is designed to assess the impact of pretreatment with puerarin (NPI-031G), a major ingredient in the plant kudzu, on alcohol drinking. Hypothesis: Short-term treatment with this compound will reduce alcohol self-administration in a simulated natural settings laboratory.
详细描述
Participants will have an opportunity to drink up to 6 beers, plus water and juice, during a 90 minute afternoon drinking session in our simulated apartment room laboratory. Drinking sessions will be conducted in the afternoon after participants take puerarin or placebo for 7 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •moderate to heavy alcohol drinkers (20+ drinks per week)
排除标准
- •alcohol dependence or treatment-seeking drinkers
- •other drug abuse or dependence
- •psychiatric disorders
研究组 & 干预措施
Puerarin
干预措施: Puerarin, Placebo (Drug)
Placebo
Sugar beet filler in capsule
干预措施: Puerarin, Placebo (Drug)
结局指标
主要结局
Amount of Alcohol Consumed
时间窗: During a 90 minute drinking session
次要结局
未报告次要终点
研究者
David M. Penetar
Psychologist
Mclean Hospital