Effect of Two Exercise Programs on Bone Strength and Architecture
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Change in Volumetric Bone Mineral Density (vBMD)
研究概览
简要总结
Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoker
- •in generally good health
- •not physically active (less than 60 minutes of purposeful exercise/week)
- •able to travel to the exercise facility a minimum of 3 times/week
排除标准
- •use of glucocorticoids
- •abnormal resting EKG
- •angina and/or evidence of acute myocardial ischemia during a treadmill test
- •resting blood pressure above 150 mmHg systolic of 90 mmHg diastolic
- •anti-resorptive drug use in the last 2 years
- •initiation of treatments that could impact bone metabolism (diuretics, hormones, bine anabolic agents) in the prior 6 months
- •dual-energy x-ray absorptiometry (DXA) t-score <+ -2.5 at the femoral neck and/or lumbar spine
- •serum vitamin D concentration <20 ng/mL
- •uncontrolled thyroid disease
- •any contraindications to regular exercise
研究组 & 干预措施
Ground Reaction Forces
Participants will have an individualized exercise program that includes walking, jogging, stair climbing, and box jumping.
干预措施: Ground Reaction Forces (Behavioral)
Joint Reaction Forces
Participants will have an individualized exercise program that includes weight lifting and aerobic rowing.
干预措施: Joint Reaction Forces (Behavioral)
结局指标
主要结局
Change in Volumetric Bone Mineral Density (vBMD)
时间窗: Baseline and 6 month
Measured via quantitative computed tomography (QCT)
Change in Areal Bone Mineral Density (aBMD)
时间窗: Baseline and 6 month
Measured via dual-energy x-ray absorptiometry (DXA)
Change in Bone Strength
时间窗: Baseline and 6 month
Measured via finite element analysis (FEA) from QCT
次要结局
- Change in 1-Repetition Maximum (1RM)(Baseline and 6 month)
- Change in Maximal Oxygen Uptake (cardiovascular fitness)(Baseline and 6 month)