Resting Energy Needs in Brain Dead Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- REE changes
研究概览
简要总结
The study will examine the resting energy need (REE) in patients suffering from brain damage. For the measurement of REE will be used a metabolic computer (which with continuous recording of breath-to-breath volume (Vt), respiratory rate (RR) of ventilation per minute volume (MV) ), of inhaled and exhaled gases (O2 and CO2) has the ability to calculate the values of VO2, VCO2 and with the help of equations the values of REE and RQ.
详细描述
This is a retrospective observational study concerning patients suffering from brain damage.
All the patients suffering from brain damage are monitored in order to examine their resting energy needs (REE). For the measurement of REE the metabolic computer (Medical Graphics, Ultima CCM, Minneapolis, USA) is used.
The main purpose of this study is to reveal the (REE) changing in patients with brain death semiology and examine if the REE changes could be related to the outcome of a patient with intracranial pathology. Moreover the study will examine if the changes in REE measurement are related to changes in flow velocities in the midbrain.
Any measurement shall be preceded by calibration of the metabolic computer pneumotachograph with a 3-liter syringe with an acceptable error of less than 9 ml / lit. The metabolic unit is calibrated for VO2 measurements with two calibration cylinders containing 21% and 12% O2 and for VCO2 measurements with calibration gases containing 5% and 0% CO2 respectively.
The measurement of flow velocities in the middle cerebral artery will be done with the transcranial Doppler using a low frequency (2 MHz) ultrasound head After their final diagnosis (brain death or not) the patients' characteristics will be compared according to the categorization as "brain dead" or not.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients entering the ICU
- •Age 18-90 years old
- •Clinical Diagnosis of brain damage
排除标准
- •Patients <18 years old and >90 years old,
- •Past history CNS disease (alzheimer's disease, multiple sclerosis, brain tumor, aneurysm) in the last 3 years
- •Past history of cachexia due to cancer
结局指标
主要结局
REE changes
时间窗: Day 0 (upon entry to ICU) up to 30 days
Changes in REE in patients with brain damage
REE and MCA correlation
时间窗: Day 0 (upon entry to ICU) up to 30 days
Correlate the REE changes with those in flow rates in MCA
MCA changes
时间窗: Day 0 (upon entry to ICU) up to 30 days
Changes in flow rates in Median Cerebral Artery (MCA) in patients with brain damage
次要结局
- Prognostic value of REE(Day 0 (upon entry to ICU) up to 30 days)
研究者
Chrysoula Pourzitaki
Principal Investigator
Aristotle University Of Thessaloniki