Clinical Trail for Study Endometrial Receptivity in RIF
试验速览
- 阶段
- 1 期
- 入组人数
- 60
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
clinical trial to improve pregnancy outcome in patient with RLF , study done on 2 phases. phase 1 to study variations of endometrial receptivity genes in this group of patient, phase 2 repeat cycle or transfer frozen embryo in proper time and after giving proper treatment
详细描述
Study design: Nonrandomized clinical trial
Inclusion criteria: women with history of recurrent implantation failure with History of transfer of at least 4 good quality embryos in at least 3 fresh or frozen cycles
-
Women age less than 40 years
-
BMI (25 - 33)
-
Non diabetic Arms of study: 2
- Women for frozen embryo transfer or New ICSI cycle fulfilling previous criteria (study arm).
- Control group of fertile patient (fertile patients receiving local mechanical contraception as a reference group). To help in identification of cut off values of all related genes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women with history of recurrent implantation failure with History of transfer of at least 4 good quality embryos in at least 3 fresh or frozen cycles
- •Women age less than 40 years • BMI (25 - 33)
排除标准
- •diabetic women
研究组 & 干预措施
1
patients with RIF
干预措施: endometrial biopsy (Diagnostic Test)
2
fertile arm as r reference for result
干预措施: endometrial biopsy (Diagnostic Test)
结局指标
主要结局
clinical pregnancy rate
时间窗: two weeks after transfer
positive intrauterine sac
次要结局
未报告次要终点
研究者
Olfat Nooh Riad Ali
professor
Cairo University