NCT01233986Unknown不适用
Prospective, Matched Case Control, Multicenter, Observational Study for the Association of Serum Apolipoprotein B-48 Level and Large arterY Atherosclerotic iSchemic Stroke(ABYSS)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- The serum level of fasting apolipoprotein B-48
研究概览
简要总结
The purpose of this study is to evaluate whether the serum apoB48 level is associated with atherosclerotic ischemic stroke.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Large artery atherosclerotic ischemic stroke group(LAA group)
- •Age over 20 years
- •Patients with symptomatic stenosis in the eligible vessels(the middle cerebral artery, anterior cerebral artery, or internal carotid artery) as assessed by MRA or CTA corresponding to the acute ischemic stroke
- •Patients without the occlusion of corresponding artery by MRA or CTA
- •The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke
- •Small vessel occlusive ischemic stroke group (SVO group)
- •Age over 20 years
- •Patients with acute ischemic stroke of basal ganglia, internal capsule, or corona radiata
- •Patients without both symptomatic and asymptomatic arterial occlusion or stenosis by MRA or CTA
- •Patients without a history of systemic atherosclerosis(for example, acute myocardial infarction, angina, peripheral arterial disease, aortic aneurysm)
- •The fasting and postprandial serum Apo B-48 level can be assessed within 72 hours after the symptom onset of ischemic stroke
排除标准
- •both LAA group and SVO group
- •Patients with cardioembolic ischemic stroke
- •Patients treated with lipid lowering agents or steroid within the previous 30 dsys
- •Patients with severe liver disease (AST >100 or ALT >100) at the time of randomization
- •Patients with endocrine disease except diabetes mellitus at the time of randomization (for example, thyroid disease, adrenal disease)
- •Patients with severe renal disease (serum creatinine >2.0mg/dl)at the time of randomization
- •chronic alcoholics or drug user
- •Patients with infection at the time of randomization
- •Patients, in the opinion of the investigator, unlikely to comply with the clinical study or unsuitable for the any other disease or reason
- •Informed consent has not been obtained
结局指标
主要结局
The serum level of fasting apolipoprotein B-48
时间窗: 72 hours within stroke onset
The serum level of postprandial apolipoprotein B-48
时间窗: within 72 hours after stroke onset
次要结局
- The serum level of fasting total cholesterol(within 72 hours after stroke onset)
- The serum level of the postprandial triglyceride(72 hours within stroke onset)
- The serum level of fasting LDL cholesterol(within 72 hours after stroke onset)
- the level of fasting HDL cholesterol(within 72 hours after stroke onset)
- the level of fasting triglyceride(within 72 hours after stroke onset)
研究者
研究点 (1)
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