Randomized controlled clinical study to evaluate the efficacy of Trunakadi taila and Khadirarishta in Dadru Kushta Dermatophytosis in children
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To evaluate the combined effect of Trunakadi Taila external application and Khadirarishta orally in clinical features of Dadru (Dermatophytosis) and quality of life parameters in children.
研究概览
简要总结
According to Acharya Charaka*, Kandu* (itching), Raga (erythema), reddish coloured Pidaka are in the form of Udgata Mandala (elevated circular lesion) is known as Dadru. Acharya Sushruta has described Dadru as Kapha Pradhana Vyadhi (predominant), and Acharya Vaghbhata and Charaka described it as Pitta Kapha Pradhana Dosha. Lakshanas of Dadru Kushta that is Raukshya, Kandu, Daha, Srava, Mandala.All the clinical features of Dadru can be very well correlated to clinical features of Tinea. Tinea infections are known as dermatophytosis or Ringworm. In Pediatric age group local application is the best line of treatment in mild to moderate ringworm manifestation The antifungal medications available in the market have some adverse effects on the human body. So, there is a need of exploring a safe and effective medicine. In modern medicine, it is treated with topical or systemic antifungal, corticosteroids which gives very fast relief but with high recurrence rate, whereas the systemic and local use of Ayurveda medicine has shown considerable effect in reducing the recurrence rate in *Dadru (*Tinea).
Dadru Kushta is managed by Shodhana, Shamanaand local application. The selected formulation of the present study is Khadirarishta which will be given orally and Trunakadi Taila for external application, as the ingredients of above Yogas possess the properties such as Kushtaghna, Kandughna and Twak Doshahara*.*
Primary objective of the study To evaluate the combined effect of Trunakadi Taila external application and Khadirarishta orally in clinical features of Dadru (Dermatophytosis). The secondary objective is To compare the combined effect of Trunakadi Taila and Khadirarishta orally with that ofGriseofulvin orally and Terbinafine 1% ointment in clinical features of Dadru (Dermatophytosis)and quality of life parameters in children.The study hypothesize that Trunakadi taila and Khadirarishta is as effective as standard care in managing Dadru (tinea)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 3.00 Year(s) 至 15.00 Year(s)（—）
入选标准
- •1 Age group.
- •3 to 15 years, irrespective of Gender, Religion, and Socio-Economic status. 2 Subjects suffering from infestation of Tinea Carporis and Tinea Cruris. 3 Subjects fulfilling the diagnostic criteria of Dadru Kushta (Dermatophytosis).
排除标准
- •Patients having chronic infection of Dadru Kushta for more than 3 years.
- •Subjects with any other skin manifestations.
- •Subjects with any other systemic disorders which may interfere with the course of study.
- •Subjects with Tinea Capitis, Tinea Barbae, Tinea Mannum, Tinea Pedis.
结局指标
主要结局
To evaluate the combined effect of Trunakadi Taila external application and Khadirarishta orally in clinical features of Dadru (Dermatophytosis) and quality of life parameters in children.
时间窗: 0th day | 8th day | 15th day | 30th day
次要结局
- 1 To assess the effect of Terbinafine 1% ointment and Griseofulvin orally in clinical features of Dermatophytosis and quality of life parameters in children.(2 To compare the combined effect of Trunakadi Taila and Khadirarishta orally with that of Griseofulvin orally and Terbinafine 1% ointment in clinical features of Dadru (Dermatophytosis) and quality of life parameters in children.)
研究者
Dr Piyush Popatrao Sonawane
JSS Ayurveda Medical College And Hospital