Ergogenic Properties of Magnesium Supplementation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Comparison interleukin 13 to placebo
研究概览
简要总结
The purpose of the proposed project is to determine if short-term dietary supplementation of magnesium will improve performance during a series of lab-based exercise tests, will favorably modify the gut-microbiota, and will augment skeletal muscle mitochondrial function.
详细描述
Magnesium is the fourth most abundant mineral in the human body. It is critical to day-to-day physiological function including the regulation of metabolism, cardiovascular function, immune function, and the operation of the nervous system. In light of its important role in physiology, dietary supplementation of magnesium has been purported to improve athletic performance, although the precise mechanism is unclear. The foci of the proposed study is the ergogenic effects of magnesium, its potential influence on gut health, and its potential ability to improve skeletal muscle function. The investigators will be studying an athletic/competitive population of endurance-trained adults. This group is likely to be the most interested in the use of magnesium to enhance athletic performance. Also, by only recruiting habitual exercisers, the variability between participants is likely to be reduced compared with if the investigators had also recruited people who are usually sedentary.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Coded bottles
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Competitive cyclists
- •Adult males and females (18 - 40 years, inclusive) who have exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous 2 years.
- •Maximal oxygen uptake (VO2max) satisfying the minimum criteria for "Good" (sex- and age-adjusted) as defined by the American College of Sports Medicine.
排除标准
- •Identification of a contra-indication to exercise during a 12-lead exercise stress test
- •Use of a magnesium supplement within the previous 4 weeks
- •Pregnancy or breast-feeding
- •Unable to perform vigorous exercise
- •History (previous diagnosis) of kidney disease
- •Use of laxatives, Zinc, diuretics, proton pump inhibitors, over the counter agents such as certain heartburn and GI/gut treatments (laxatives) which contain magnesium, Zinc or other high dose cations which reduce absorption of Magnesium
结局指标
主要结局
Comparison interleukin 13 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison of indirect Calorimetry (VO2max) to placebo
时间窗: After 8 days of intervention
During a standard stress test VO2 max will be measured
Comparison interleukin 2 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison of power output to placebo
时间窗: After 9 days of intervention
Cycling for 30 seconds
Comparison of lactate threshold to placebo
时间窗: After 8 days of intervention
During a standard stress test lactate threshold will be measured
Comparison interferon gamma to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 1 beta to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 7 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 8 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 10 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison of completion of time trial to placebo
时间窗: After 9 days of intervention
Amount of time it takes to cycle 10 kilometers
Comparison Human Granulocyte Macrophage Colony-Stimulating Factor to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison High-sensitivity C-reactive protein to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison of Mitochondrial Function to placebo
时间窗: After 8 days of intervention
Assessed via high-resolution mitochondrial respirometry in permeabilized skeletal muscle.
Determination of differentially abundant microbiota in feces of collected during treatment compared to placebo
时间窗: After 9 days of intervention
Assessed via 16s ribosomal ribonucleic acid microbial profiling
Comparison Tumor Necrosis Factor alpha to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison of Shannon and Faith's microbiota diversity scores in feces to placebo
时间窗: After 9 days of intervention,
Assessed via 16s ribosomal ribonucleic acid microbial profiling
Calculation and ordination of B-diversity scores for all fecal samples to assess clustering
时间窗: After 9 days of intervention
Assessed via 16s ribosomal ribonucleic acid microbial profiling
Comparison of abundant microbiota to markers in feces to placebo
时间窗: After 9 days of intervention
Assessed via Linear discriminant analysis Effect Size algorithm
Comparison interleukin 4 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 5 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 6 to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
Comparison interleukin 12 (p70) to placebo
时间窗: After 9 days of intervention
Assessed via 13-plex human T-cell cytokine panel
次要结局
未报告次要终点
研究者
Christopher Bell
Associate Professor
Colorado State University