Evaluation of the Association of Serum Growth Differentiation Factor-15 Levels With Clinical Findings and Electrophysiological Severity in Patients With Carpal Tunnel Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Serum Growth Differentiation Factor-15 (GDF-15) Concentration
研究概览
简要总结
This observational study aims to evaluate serum Growth Differentiation Factor-15 (GDF-15) levels in patients with idiopathic carpal tunnel syndrome compared with asymptomatic controls. The study will also assess the associations between serum GDF-15 levels and clinical and electrophysiological characteristics of carpal tunnel syndrome.
详细描述
This is a single-center observational study including patients with idiopathic carpal tunnel syndrome and asymptomatic controls. Serum GDF-15 levels will be evaluated and their associations with clinical and electrophysiological characteristics will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years.
- •Written informed consent.
- •For the patient group: idiopathic carpal tunnel syndrome confirmed by clinical and electrophysiological evaluation.
- •For the control group: asymptomatic individuals without a previous diagnosis of carpal tunnel syndrome and without clinical signs of carpal tunnel syndrome.
排除标准
- •Diabetes mellitus.
- •Hypothyroidism.
- •Rheumatoid arthritis or other inflammatory rheumatic diseases.
- •Pregnancy.
- •Cervical radiculopathy or polyneuropathy.
- •Previous carpal tunnel or wrist surgery.
- •History of wrist trauma or fracture.
- •Corticosteroid injection into the carpal tunnel within the previous 3 months.
- •Malignancy.
- •Chronic kidney or liver disease.
- •Active infection or autoimmune disease.
- •Serious systemic conditions that may affect serum GDF-15 levels.
结局指标
主要结局
Serum Growth Differentiation Factor-15 (GDF-15) Concentration
时间窗: At baseline
Serum Growth Differentiation Factor-15 (GDF-15) concentration will be quantitatively measured from serum samples using a sandwich enzyme-linked immunosorbent assay (ELISA). GDF-15 concentration will be reported in picograms per milliliter (pg/mL).
次要结局
- Correlation Between Serum GDF-15 Concentration and Boston Carpal Tunnel Questionnaire Symptom Severity Scale Score(At baseline)
- Correlation Between Serum GDF-15 Concentration and Boston Carpal Tunnel Questionnaire Functional Status Scale Score(At baseline)
- Correlation of Serum GDF-15 With Hand Grip Strength(At baseline)
- Serum GDF-15 Concentration According to Electrophysiological Severity of Carpal Tunnel Syndrome(At baseline)
- Correlation of Serum GDF-15 With Pain Severity(At baseline)
- Correlation of Serum GDF-15 With Numbness Severity(At baseline)
研究者
Zeynep Karakuzu Güngör
Physical Medicine and Rehabilitation Specialist
Kanuni Sultan Suleyman Training and Research Hospital