EFFects of Thrombophilia on the Outcomes of Assisted Reproduction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 687
- 试验地点
- 1
- 主要终点
- Live birth rate
研究概览
简要总结
Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle placentation. Some studies have suggested a role of thrombophilia in the failure of assisted reproductive techniques although this association has been recently questioned. The scope of this study is to evaluate the effect of thrombophilia on the implantation rate and live birth rate in women undergoing ART.
Design: prospective, observational study Primary end-point: live birth rate. Secondary end-points: implantation rate, venous thromboembolic events during ART up to 6 weeks post-partum
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women undergoing ART
- •age 18 years or older
排除标准
- •ongoing anticoagulant therapy
- •previous venous thromboembolism
- •no informed consent
结局指标
主要结局
Live birth rate
时间窗: Participants will be followed for the duration of the pregnancy, an expected average of 9 months
次要结局
- implantation rate(Participants will be followed from the implantation to the ultrasonography to document the gestational sac, an expected average of 7 weeks)
研究者
Marcello Di Nisio
Principal Investigator
G. d'Annunzio University