NL-OMON37583已完成不适用
Effects of the gut flora on serum LDL cholesterol concentrations in slightly hypercholesterolemic subjects - Gut flora and lipid metabolism
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- aged between 18-70 years
- •- mean serum total cholesterol concentrations between 5.0 - 8.0 mmol/L
排除标准
- •- mean serum triacylglycerol > 3.0 mmol/L
- •- use of oral anticonceptives (OAC)
- •- pregnant or breastfeeding women
- •- subjects with kidney insufficiencies (defined as creatinine clearance <30 mL/min).
- •- unstable body weight (weight gain or loss >2 kg in the past 3 months)
- •- known allergy to antibiotics
- •- indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus
- •- use of medication or a medically prescribed diet known to affect lipid or glucose metabolism
- •- active cardiovascular disease like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebro vascular accident)
- •- severe medical conditions that might interfere with the study such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis
- •- abuse of drugs
- •- more than 21 alcohol consumptions per week for men and 14 consumptions for women
- •- not or difficult to venipuncture as evidenced during the screening visits
- •- use of an investigational product within the previous 30 days
- •- not willing to stop the consumption of products rich in plant stanol or sterol esters 3 weeks before the start of the study
- •- not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study
- •- use of gastric acid inhibitors, laxantia, prebiotica, probiotica and antibiotica for at least one month before the start of the study and during the study
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