Nutritional Therapy to Prevent Progression of Acute Kidney Injury to Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 主要终点
- feasibility of the LPD-K diet
研究概览
简要总结
This study will evaluate patients who have an episode of moderate to severe acute kidney injury (AKI) and are followed in a focused post-AKI clinic. After patients present signs of kidney recovery and before hospital discharge, patients who give consent will be enrolled in the study. At the first post-AKI clinic visit, patients will be randomly allocated to follow a normal (ad-lib) or a low protein diet (LPD) for 3 months. Patients allocated to a LPD will receive a drug called Ketosteril. This drug allows the intake of essential amino acids while minimizing the amino-nitrogen intake, what in excess, can be bad for the recovered kidney. The investigators will evaluate the nutritional parameters and the kidney recovery of all patients and compare these parameters in those two groups.
详细描述
This is a pilot single center, randomized controlled, trial of patients who have an episode of Stage 2/3 AKI and are followed in a focused post-AKI clinic. Patients will be randomize to either; a. LPD-K diet containing 0.6 g protein/kg per day, phosphorus 5-10 mg/kg/day, Ketosteril 1 capsule per 5 kg body weight/day divided over three doses (max 8 capsules per dose) or b. ad lib diet. Ketosteril should be takes daily during meals and the tablets must not be chewed. Ingestion during meals facilitates proper absorption and the metabolisation into the corresponding amino acids.
After the initial assessment, those randomized to LPD-K will be on this diet for a maximum of 90 days. Additional interventions will include dietary counselling and questionnaire in both groups. We would aim for maintaining serum bicarbonate levels ≥ 22meq/L in both groups.
Evaluation of renal function will be performed using blood and urine tests. In addition, specimens will be collected in a bio-repository, and tested for biomarkers of renal structural damage. Comprehensive nutritional assessment will be performed by a dietitian, along with bioelectrical impedance measurements, blood and urine tests. 24-hour urine urea nitrogen and food records will be used to estimate the protein intake of each individual. Quality of well-being will be assessed using a standardized tool such as Euro Quality of Life (EQ-5D), Charlson Index, and Short Form 8 (SF8) or equivalent. Relevant clinical events (adherence to follow-up, death, hospitalization, renal recovery, repeat AKI episodes) will be tracked throughout the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Duration of stage 2/3 AKI episode ≥ 72 hrs and ≤ 21 days
- •Total hospital stay ≤ 21 days
排除标准
- •Baseline Chronic Kidney Disease Stage 4 or higher (estimated Glomerular Filtration Rate (eGFR)) <30ml/min/1.73m2) prior to their AKI episode
- •Patients dialysis dependent at hospital discharge
- •Dialysis dependency > 14 days at time of enrolment
- •eGFR exclusion criteria:
- •for patients that required dialysis during hospital stay - measured GFR less than 15ml/min and/or urine output less than 500ml at hospital discharge
- •for patients with known baseline serum creatinine (SCr) - renal recovery with an eGFR more than 80% from baseline at hospital discharge
- •for patients with unknown previous renal function - eGFR > 60ml/min/1.73m2 at time of hospital discharge
- •Suspected or biopsy proven glomerulonephritis as cause of AKI
- •Obstructive nephropathy as cause of AKI.
- •Kidney transplant recipient and patients in the kidney transplant list
- •Chronic liver disease
- •High likelihood of re-hospitalization or death in the following 6 months, ascertained by physician in charge of the patient.
- •Hypercalcemia - Ca > within one standard deviation of reference level upper limit or albumin corrected
- •Lactating or pregnant woman or woman planning to become pregnant within the timeframe of the study
- •Inability to follow up study procedures for at least 6 months
- •Unwillingness to give consent
- •Institutionalized individuals (prisoners, significant mental illness, or nursing home residents)
- •Body weight <70% or >150% of standard body weight
- •History of phenylketonuria or other major disorder of amino acid metabolism
- •Hypersensitivity to the active substances or to any of the excipients of Ketosteril.
结局指标
主要结局
feasibility of the LPD-K diet
时间窗: 6 months
Feasibility: assess the compliance with diet and drug. Compliance to the assigned protein prescription will be estimated at each visit during the intervention period by nutrient intake data obtained from 3-day food records and the estimated protein intake calculated from urinary nitrogen appearance in 24-hour urine samples. Treatment compliance will be assessed by counting returned tablets.
次要结局
- safety of the LPD-K diet(6 months)
- degree of recovery of renal function(6 months)
- rate of recovery of renal function(6 months)
研究者
Ravindra Mehta
Professor of Medicine
University of California, San Diego