Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization Versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars With Chronic Peri-apical Periodontitis
试验速览
- 阶段
- 不适用
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Post-operative Pain
研究概览
简要总结
randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical Periodontitis
详细描述
it will be done in 2 visits where in the firist visit, i will finish cleaning and shaping of the canals and inject double antibiotic paste as intracanal medication.
in the second visit, removal of intracanal medication then obturaton of the canals in the control group. while in the intervention group,over instrumentation of the canals beyond the working length using k-file size 20-35 to establish bleeding in the canals.then blood sample is collected for PRP preparation then injected into the canal.the patient will record post operative pain 6,12,24,48 hours then 3,4,5 days later.then they will do CBCT at 6, 12 months after the treatment to assess peri-apical healing
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 35 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Medically free patients, between 18-40 years
- •Patients with necrotic pulp in mandibular molar permanent teeth with closed apex
排除标准
- •Illiterate patient
- •Patients with systemic diseases
- •Pregnant women
- •Patients that have allergy to ciprofloxacin or metronidazole
- •Teeth that:
- •Have vertical root fracture, coronal perforation, and calcification.
- •re-treatment cases
- •Non restorable
- •Patients that have T.M.J. disorder
研究组 & 干预措施
Revascularization
platelet rich plasma injected in the canals
干预措施: Platelet rich plasma PRP (Procedure)
root canal treatment
endodontic treatment obturated with gutta percha
干预措施: root canal treatment (Procedure)
结局指标
主要结局
Post-operative Pain
时间窗: 5 days
postoperative pain evaluated using NRS scale It is a numerical rating scale from 0-10 with 0 representing no pain and 10 representing worst pain
次要结局
- healing(12 months)
研究者
yassmin Elsayed Ahmed
Assisstant lecturer-endodontic department
Cairo University