Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin
试验速览
- 阶段
- 不适用
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Occurrence of PPMI post elective PCI
研究概览
简要总结
The aim of this research is to study the effect of a loading dose of colchicine on the occurrence of periprocedural myocardial infarction (PPMI) in elective percutaneous coronary intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients hospitalized with troponin negative events and scheduled for elective PCI
排除标准
- •Significant renal dysfunction
- •Significant liver dysfunction
- •Severe left ventricular dysfunction
- •Severe low weight
- •Chronic colchicine treatment
研究组 & 干预措施
Control Group
Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment
干预措施: Standard of care treatment prior to elective PCI (Drug)
Early colchicine loading dose
Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment plus colchicine loading dose 12-24 hours before PCI
干预措施: Colchicine Loading Dose (Drug)
Late colchicine loading dose
Stable coronary artery disease patients who have been assigned to elective PCI and who will be given standard of care treatment plus colchicine loading dose one hour prior to PCI
干预措施: Colchicine Loading Dose (Drug)
结局指标
主要结局
Occurrence of PPMI post elective PCI
时间窗: 24 hours post PCI
Occurrence of PPMI post elective PCI and its relation to defensin levels
次要结局
- Traditional inflammatory markers(24 hours post PCI)
- Major adverse cardiovascular events(30 days)