Pressure Pain Tolerance in Relation to Balance and Strength in Children With Sickle Cell Anemia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Pressure pain tolerance
研究概览
简要总结
Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS).Cells with sickle cell hemoglobin are stiff and sticky. When they lose their oxygen, they form into the shape of a sickle or crescent. This can cause pain and tissue damage. Significant decrease in exercise capacity was seen in sickle cell anemic children. In the absence of a guidelines that can guide the prescription of exercise in SCD children. This study is a step for determine the forms of prescription of pain on the balance and muscle strength to build up in future studies a safety of physical exercises for children with sickle cell anemia and improve their functional abilities.
详细描述
Sickle cell anemia is a serious life-limiting and potentially life-threatening condition that causes disruption in the lifestyle of the affected child. Pain is a common and severe symptom of sickle cell disease (SCD) and is the major reason that patients seek health care services. Some researchers supported the fact that an important impairment in balance control and muscle strength in children with sickle cell disease due to pressure pain tolerance problems and other factors. Significant decrease in exercise capacity was seen in sickle cell anemic children. The altered muscle function and balance observed in SCD children may collectively be the result of pressure pain tolerance impairment. As your physical fitness improves, your body becomes more efficient at getting oxygen into the bloodstream and transporting it to the working muscles. Along this observational correlational study design; Eighty children from both sexes will be participated in this study. Forty normal healthy children will be selected from primary governmental schools at Alexandria governorate and forty children with sickle cell anemia will be selected from Alexandria University Students Hospitals For evaluation of muscle strength hand held dynamometer (Lafayette) is one of the best methods to detect the muscle strength. It is an ergonomic hand-held device for objectively quantifying muscle strength
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
盲法说明
Forty normal healthy children from primary governmental schools at Alexandria governate, and Forty children with sickle cell anemia from Alexandria University Students Hospitals.
入排标准
- 年龄范围
- 9 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range range was 9-14 years old.
- •Could follow given instructions.
- •Children with Sickle cell anemia were medically stable, and take their medications regularly.
- •Children with Sickle cell anemia had experience of chronic pain that lasts more than 6 months.
- •All children with Sickle cell anemia have average weight, height, and body mass index based on their age percentiles.
- •All normal healthy children did not participating in regular sport activities, particularly including lower limb strengthening.
排除标准
- •Defined cardiovascular or respiratory disorders.
- •Renal failure.
- •Myocardial infarction, mainly within last month.
- •Unstable angina.
- •Recent thoracoabdominal surgery.
- •Thoracic or abdominal aneurysm or current pneumothorax.
- •Painful vaso-occlusive crises.
- •Muscular contractures, Joints' stiffness, or deformities.
- •Neuromuscular problems i.e., myositis or peripheral neuropathy.
结局指标
主要结局
Pressure pain tolerance
时间窗: Baseline of the study.
Pressure pain tolerance measured via digital pressure algometer. It determines the pressure amount could be tolerated over quadriceps. This will represented chronic pain among Sickle cell anemia children in order to aid in diagnosis of hyperalgesia thus provide insight into their management strategies. Digital pressure algometer determines enables the rater to quantify the mechanical sensitivity to pain and the recovery of underlying problems or soreness levels in a semi-objective manner.
Balance assessment
时间窗: Baseline of the study.
Balance assessed via HUMAC balance system to define musculoskeletal involvement in sickle cell anemia children. HUMAC balance system is an electronic balance board connected with laptop running HUMAC balance system software.
Lower limb muscle strength
时间窗: Baseline of the study.
Lower limb muscle (Quadriceps) strength evaluated via Lafayette hand held dynamometer to evaluate voluntary isometric contraction. Hand held dynamometer has a good to excellent reliability and validity mainly for proximal musculatures.
次要结局
未报告次要终点
研究者
Adly A Adam
Lecturer Physical Therapy
Cairo University