miRNA and FGF21 Profile in First Trimester and Efficacy of Gestational Diabetes Prediction and Pregnancy Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- miRNA profile
研究概览
简要总结
The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.
Participants will be retrieved blood sample during first trimester and undergone 100 gm OGTT (oral glucose challenge test) during 24-28 weeks of gestation.
详细描述
Pregnant women who attended antenatal care at Maharaj Nakorn Chiang Mai hospital during first trimester were recruited.
Participants received routine standard prenatal care except,
- additional blood test during 11-13 week 6 days (Blood was collected for further analysis)
- performed 75gm OGTT during 24-28 week
Baseline data and pregnancy outcome were reviewed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 45 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •singleton pregnant women who attend at our clinic in first trimester
排除标准
- •known underlying disease such as chronic hypertension, pregestational diabetes, SLE
- •normal structural fetal anatomical screening
- •incomplete obstetric data
研究组 & 干预措施
Pregnancy with GDM
Pregnant women who positive test for 100gm OGTT (abnormal 2 or more blood glucose level according NDDG (National Diabetes Data Group) criteria)
干预措施: blood draw (Other)
Pregnancy without GDM
Pregnant women who negative test for 100gm OGTT
干预措施: blood draw (Other)
结局指标
主要结局
miRNA profile
时间窗: within 1 month after blood drawn
miRNA profile in first trimester of pregnancy and efficacy for GDM prediction
次要结局
- FGF21 profile(6 months after blood drawn)
研究者
Kuntharee Traisrisilp
Associate Professor
Chiang Mai University