Delivery Room Practice Change Following the Initiation of the NICHD SUPPORT Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,843
- 试验地点
- 1
- 主要终点
- Endotracheal intubation in the delivery room
研究概览
简要总结
This study was designed to analyze whether initiation of the NICHD Neonatal Research Network SUPPORT trial was followed by a change in frequency of endotracheal intubation the delivery room in non-participants and whether these changes were associated with changes in management and outcomes.
The investigators hypothesized that the investigators would observe following the initiation of the SUPPORT trial a 33% reduction in the rate of intubation in the delivery room among non-participants preterm infants at Parkland Memorial Hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 24 Weeks 至 35 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All babies born at Parkland Memorial Hospital with gestational age at least 24 weeks and less than 35 weeks between 01/2003 and 06/2010
排除标准
- •Infants receiving comfort care
- •Those with major congenital anomalies
- •Those enrolled in the SUPPORT trial
结局指标
主要结局
Endotracheal intubation in the delivery room
时间窗: In the delivery room (1 day)
Frequency of endotracheal intubation in the delivery room
次要结局
- Continuous positive airway pressure in the delivery room(In the delivery room (1 day))
- Endotracheal intubation in the first four hours after admission(First four hours after admission)
- Endotracheal intubation until four hours after admission(Between birth and 4 hours after admission)
- Admninistration of surfactant(Any time between birth and 2 days of age)
- Pneumothorax(Any time before discharge or transfer or 12 months of age (whichever comes first))
- Bronchopulmonary dysplasia(28 days)
- Necrotizing enterocolitis(Any time before discharge or transfer or 12 months of age (whichever comes first))
- Duration of mechanical ventilation(Until discharge or transfer or 12 months of age (whichever comes first))
- Maximum oxygen concentration(Until discharge or transfer or 12 months of age (whichever comes first))
- Severe retinopathy of prematurity(Until discharge or transfer or 12 months of age (whichever comes first))
- Mortality(Until discharge or transfer or 12 months of age (whichever comes first))
- Severe brain lesion on imaging(Any time before discharge or transfer or 12 months of age (whichever comes first))
研究者
Luc Brion
Professor of Pediatrics
University of Texas Southwestern Medical Center