CANTO - Cell-free DNA in Acute Stroke
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Stroke Etiology
研究概览
简要总结
Cell-free DNA (cfDNA) is an important pro-inflammatory and prothrombotic mediator. With this study the investigators aim to gain new insights into the role of cfDNA in stroke and to perform a combined analysis of cfDNA in the hyperacute phase of the disease using blood and thrombus analyses. The main objectives are to analyse cfDNA in different stroke etiologies, to investigate the relationship between cfDNA and important procedural factors such as secondary embolisation and reperfusion outcomes, to analyse the correlation between blood and thrombus content of cfDNA and to investigate the specific source of cfDNA in distinct stroke subtypes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute ischemic stroke due to large vessel occlusion (LVO) who require mechanical thrombectomy (detected in CT-Scan or MRI-Scan)
- •18 years of age
排除标准
- •Patients currently undergoing immunological therapies.
- •Patients with immunological diseases
- •Patients with systemic infections at the time of admission
结局指标
主要结局
Stroke Etiology
时间窗: at day 1
Descriptive comparison of cell-free DNA in cerebral thrombi regarding stroke etiology
次要结局
- Correlation cfDNA concentration and perfusion outcome(at day 1)
- Correlation cfDNA concentration and secondary embolism(at day 1)
- Correlation cfDNA concentration and thrombus fragmentation.(at day 1)
- Measures of cfDNA as a marker of systemic inflammation(at day 1)
- 90-day functional outcomes(up to 3 month)