NCT01039935已完成不适用
Genetic Basis of Odor Discrimination
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 512
- 试验地点
- 1
- 主要终点
- Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors
研究概览
简要总结
Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Current non-smokers
排除标准
- •Current smokers
- •Allergy to fragrances or smells of any kind
- •Active head cold, upper respiratory infection, or seasonal nasal allergies
- •History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
- •Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism
结局指标
主要结局
Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors
时间窗: 3 years
次要结局
- concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors(3 years)
研究者
研究点 (1)
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