Clinical Application of Sulfhydryl Oxidase QSOX1 as a New Biomarker of Colon Cancer
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 主要终点
- Detection of RNA for early rapid diagnosis of colon cancer.
研究概览
简要总结
The goal of this observational study is to determine whether the secreted protein QSOX1 can be used as a molecular marker for early rapid diagnosis and accurate treatment of colon cancer.
详细描述
The project mainly selects the tumor group represented by colon cancer and the corresponding healthy people as the control group, with about 100 cases in each of the two groups. Mainly collect blood and tumor tissue samples of patients, detect the expression of QSOX1 in the above samples, and explore the role in the diagnosis and prognosis evaluation of colon cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Colon cancer was confirmed by colonoscopic pathology.
- •No local or systemic treatment was performed before operation.
- •Complete clinical data.
排除标准
- •Combined with benign diseases of colon, such as ulcerative colitis, colon adenoma and colon polyp.
- •Other tumors other than colon cancer.
结局指标
主要结局
Detection of RNA for early rapid diagnosis of colon cancer.
时间窗: 6 months
RT-PCR was used to detect the RNA levels of QSOX1 in the tumor and control groups.
Detection of protein for early rapid diagnosis of colon cancer.
时间窗: 6 months
Western blotting was used to detect the protein levels of QSOX1 in the tumor and control groups.
次要结局
未报告次要终点
研究者
YunqiuWang
Dr
Qianfoshan Hospital