The Impact of Systemic Light Chain Amyloidosis on Eyes and Its Appendages
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Conjunctival Mass
研究概览
简要总结
Study Purpose and Principle: Amyloidosis is a group of diseases characterized by the deposition of amyloid proteins in tissues and organs throughout the body, with common affected organs including kidneys, heart, nervous system, gastrointestinal tract, and liver. Nowadays, nearly 40 different proteins have been found to form amyloid fibrils in body, among which Systemic Light Chain (AL) Amyloidosis is the most common type of systemic amyloidosis. AL amyloidosis is a plasma cell disorder, with its precursor protein originating from free light chains produced by abnormal plasma cell clones, which form amyloid substances that deposit in tissues and organs causing lesions. In terms of incidence, the incidence of AL amyloidosis is 8-10 cases per million person-years in the United States and is considered a rare disease in our country. AL amyloidosis has an insidious onset, diverse clinical manifestations, and is prone to misdiagnosis and missed diagnosis in clinical practice. The prognosis also has strong heterogeneity and is closely related to the extent of organ involvement at the time of diagnosis. In the past, the incidence of eye involvement in systemic AL amyloidosis patients was low, with various manifestations, only reported as case reports, and not regularly followed up with systemic treatment. Based on this, this project aims to assess the involvement of eyes and its appendages in patients with different stages of systemic light chain amyloidosis, with the goal of clarifying the ocular manifestations of this systemic disease and exploring early diagnostic indicators for the eye.
Primary Objective: To assess the involvement of the anterior segment of the eye, as well as the extraocular soft tissues and muscles, in patients with systemic light chain amyloidosis.
Secondary Objective: To assess the neuro-ophthalmic manifestations and changes in retinal choroidal blood flow in patients with systemic light chain amyloidosis.
Study Design: Observational study.
Study Population and Expected Enrollment: 80 patients with systemic light chain amyloidosis, 50 normal controls.
Study Duration: Six months of follow-up after the last subject is diagnosed and enrolled.
Intervention: Experimental Group: Patients with systemic light chain amyloidosis; Control Group: Subjects without systemic diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with "Systemic Light Chain Amyloidosis";
- •No other severe systemic underlying diseases that affect the examination;
- •Subjects voluntarily participate in this study, sign the informed consent form;
- •Age between 18-80 years old, no gender restrictions.
排除标准
- •Patients with eye diseases of clear causes such as ocular surface malignant tumors, corneal perforation, severe eye trauma, etc.;
- •Patients with nystagmus;
- •Severe ocular scar diseases; conjunctival scars with fornix shortening;
- •Current signs of infection, including fever and undergoing antibiotic treatment;
- •Mental abnormalities;
- •Pregnant or breastfeeding women, or women planning to become pregnant within 2 years;
- •NYHA Class IV: Heart disease patients cannot engage in any physical activity, with heart failure symptoms even at rest, and worsening with physical activity;
- •NT-proBNP > 8,500 ng/L.
- •Control Group
- •Inclusion Criteria:
- •Stable general condition, not patients with "Systemic Light Chain Amyloidosis";
- •No other severe systemic underlying diseases that affect the examination;
- •Subjects voluntarily participate in this study, sign the informed consent form;
- •Age between 18-80 years old, no gender restrictions.
- •Exclusion Criteria:
- •Patients with eye diseases of clear causes such as ocular surface malignant tumors, corneal perforation, severe eye trauma, etc.;
- •Patients with nystagmus;
- •Severe ocular scar diseases; conjunctival scars with fornix shortening;
- •Current signs of infection, including fever and undergoing antibiotic treatment;
- •Mental abnormalities;
- •Pregnant or breastfeeding women, or women planning to become pregnant within 2 years.
结局指标
主要结局
Conjunctival Mass
时间窗: Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.
Conjunctival Mass: The size of the yellowish-pink waxy mass on the bulbar or palpebral conjunctiva (if present, additional conjunctival confocal microscopy examination is performed to clarify the microscopic morphology of the mass).
Subconjunctival Hemorrhage Grading
时间窗: Each system light chain amyloidosis patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.
Subconjunctival Hemorrhage: No conjunctival congestion is scored 0; mild diffuse conjunctival congestion is scored 1; moderate diffuse conjunctival congestion, with noticeable congestion near the fornices, is scored 2; severe diffuse conjunctival congestion with subconjunctival hemorrhage is scored 3.
次要结局
- Periocular Purpura(Each system light chain amyloidosis patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Ptosis(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Vitreous Opacity(Each system light chain amyloidosis patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Cup-to-Disc Ratio (C/D)(Each system light chain amyloidosis patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Visual Field(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Retinal Microvasculature(Each system light chain amyloidosis patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Retinal Nerve Fiber Layer Thickness(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Choroidal Thickness(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Cornea(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Visual Acuity(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)
- Non-contact Intraocular Pressure(Each patient will be followed up once every 2 months, for a total of 4 follow-ups, over a 6-month period, to observe any ocular complications and progression.)