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临床试验/NCT06526780
NCT06526780尚未招募不适用

Bronchoscopy Versus Imaging in Diagnosis of Airway Diseases in Critically Ill Children

Assiut University0 个研究点目标入组 100 人开始时间: 2024年11月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
100
主要终点
Visualization of airway abnormalities by computed tomography scan

研究概览

简要总结

Patients with suspected airway illness often go through a diagnostic assessment that includes chest radiographs, Computed tomography scans, and fiber optic bronchoscopy.

详细描述

A correct diagnosis is necessary for effective therapy of airway illness. Usually necessary for these invasive treatments. The "gold standard" for tracheobronchial pathology identification and diagnosis is rigid or fiber optic bronchoscopy. Fiber Optic is a procedure that is generally safe, although it can have negative effects, particularly in patients who are at greater risk. Therefore, it is important to continually develop and improve non-invasive procedures that enable airway examination.

The laryngotracheal and bronchial airway is affected by a wide range of diseases, and imaging is essential for assessing these anomalies. The location, scope, and type of these lesions may be determined with great accuracy using computed tomography.

Bronchoscopy allows direct visualization of trachea and bronchi by rigid open tube bronchoscope or flexible fiber optic scope. Detailed evaluation of airways with bronchoscopy offers advantages over other diagnostic tools and allows interventional procedures such as biopsy of lesions, removal of foreign bodies, dilatations of stenosis and obtaining samples for cytological and microbiologic analysis.

Bronchoscopy can be performed either by rigid or flexible instruments depending on the needs of patients. The pediatric airway is notably different from adults. It is smaller in size, larynx and tracheal proportion is more as compared to adults and epiglottis is more posterior and narrower .

Fiber Optic bronchoscopy with or without bronchoalveolar lavage is particularly important in the diagnosis and treatment of specific respiratory problems in critically ill infants and children hospitalized in the pediatric Intensive care unit.These comprise situations such as segmental lung collapse, pulmonary infections including community-acquired and ventilator-associated pneumonia, pulmonary infections in immunocompromised hosts, and pulmonary bleeding. In addition, bronchscopy has a special role in airway problems in very sick pediatric patients. It may be crucial in intubation of the difficult airways and in the assessment of airway anomalies.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
1 Month 至 18 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Age 1 month: 18 years.
  • Critically ill patients with suspected airway diseases for the following indications:
  • Difficult intubation.
  • extubation failure (defined as the replacement of an endotracheal tube within <48 h after extubation).
  • Persistent stridor. •Acute unexplained respiratory distress.• Localized hyperinflation.
  • Suspected foreign body.
  • Persistent and recurrent wheezes.
  • Persistent and recurrent atelectasis.
  • Unexplained hemoptysis

排除标准

  • Age ( < 1month and > 18 years )
  • Severe hypoxemia
  • Hemodynamic instability
  • Uncorrected bleeding diathesis
  • Unresolved lung infection

结局指标

主要结局

Visualization of airway abnormalities by computed tomography scan

时间窗: During procedure

Assessment of airway by computed tomography scan with virtual bronchscopy

Visualization of airway abnormalities by bronchscopy

时间窗: During procedure

Direct visualization of airway by bronchscopy

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

AA Nagy

Principal investigator

Assiut University

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