NCT00296894已完成2 期
TNF-Blockade for the Treatment of Erosive Osteoarthritis (OA) of Interphalangeal Finger Joints: Randomized, Double Blind, Placebo-Controlled Cross-Over Study to Evaluate the Efficacy of Adalimumab 40 mg SC Every Other Week in Patients With Erosive Osteoarthritis of the Interphalangeal Finger Joints
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Evaluation of x-rays
研究概览
简要总结
Patients will be randomized into two groups (1/1) during one year:
- 40 mg adalimumab subcutaneously (sc) every other week
- placebo
The effect on x-rays and clinical parameters will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clear erosive image on x-ray of at least one interphalangeal finger joint
排除标准
- 未提供
研究组 & 干预措施
1
Experimental
Drug - adalimimab sc
干预措施: Adalimumab (40 mg sc every other week) (Drug)
2
Placebo Comparator
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Evaluation of x-rays
Evaluation of clinical parameters (pain, daily functioning, etc.)
次要结局
未报告次要终点
研究者
研究点 (1)
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