NCT01825148已完成不适用
Clinical Proof-of-principle of the Determination of the Beta Cell Mass in Vivo by SPECT Imaging With the 111-In-labeled GLP-1 Analogue DTPA(Diethylenetriamine Pentaacetic Acid)-[K40]-Exendin 4
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- pancreatic uptake of radiolabeled Exendin
研究概览
简要总结
The purpose of the study is to determine whether there are differences in pancreatic uptake of the radiotracer between healthy individuals and patients with type 1 diabetes. If T1D patients have a markedly reduced uptake, the compound may be suitable for estimation of pancreatic beta cell mass, i.e. the cells in the pancreas that produce insulin.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •type 1 Diabetes
排除标准
- •breast feeding
结局指标
主要结局
pancreatic uptake of radiolabeled Exendin
时间窗: 7 days
uptake will be given as counts per MBq injected activity as determined by calibrated SPECT/CT scanner with attenuation correction.
次要结局
未报告次要终点
研究者
Martin Gotthardt
Prof. Dr.
Radboud University Medical Center
研究点 (1)
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