Comparison Of Efficacy Of Nebulised Levosalbutamol Vs Levosalbutamol Metered Dose Inhaler-Spacer: A Single Centre Open Label Randomized Controlled Trial In Hospitalized Children With Wheezing

Inhospital, nebuliser and MDI-spacer aretwo mainstay aerosol drug delivery method for β 2 agonists administration, but due to the lack of awarenessand lack of understanding of the inhalational technique MDI –spacer is notcommonly employed in the acute management. However,in clinical routine and under the supervision of trained pro­fessionals, theMDI-spacer technique may be just as effec­tive as nebulisation. Although the efficacy of nebulization is broadly acknowledged, the method hasseveral disadvan­tages. Studies show that nebulization may be ineffective indelivering aerosolized medicine compared to the combina­tion MDI-spacer.Incase of acute wheezing current guidelines recommend the use of short-actingbronchodilators (β 2 agonists) inhalation to reverse airflow obstruction andtreat patients. Thatbeing said, the purpose of this study is to comparethe efficacy of levosalbutamol aerosol therapy given via MDI-spacer to that givenvia nebulizer in hospitalised children with wheezing by using pulmonary score.