The Joint Effect of Air Pollution and Exercise on Cognitive Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 试验地点
- 2
- 主要终点
- Change of transcriptions
研究概览
简要总结
A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise [HIIT], moderate intensity of aerobic exercise [MICT] and control group [CONT]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).
详细描述
Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10.
Exercise intervention program including HIIT, MICT and Stretching (Control) group :
The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation.
MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation.
Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Participants and investigators are blinded, and part of the outcome assessors are blinded.
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No regular exercise in the past six months;
- •Healthy people without history of disease;
- •Aged between 20 and 30 years old.
排除标准
- •Professional athletes;
- •Regular exercise in the past six months;
- •People who are injured or have a history of disease in the past six months;
- •People who have a history of taking medicine in the past six months.
研究组 & 干预措施
Moderate intensity continuous training
MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise.
干预措施: Exercise (Behavioral)
High intensity intermittent training
HIIT exercise program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes.
干预措施: Exercise (Behavioral)
HIIT with pollution reduction
HIIT program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Exercise (Behavioral)
HIIT with pollution reduction
HIIT program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Air purification (Behavioral)
MICT with pollution reduction
MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Exercise (Behavioral)
MICT with pollution reduction
MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Air purification (Behavioral)
Stretch control group
Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.
干预措施: Exercise (Behavioral)
Control with pollution reduction
Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.
Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Exercise (Behavioral)
Control with pollution reduction
Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.
Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.
干预措施: Air purification (Behavioral)
结局指标
主要结局
Change of transcriptions
时间窗: Before and after acute exercise (about 30 minutes).
The molecular response of exercise and environment through the measurement of peripheral blood
Change of cognitive function
时间窗: Before and after acute exercise (about 30 minutes).
Cognitive function measured by computer-based tasks including executive function
Change of biomarkers
时间窗: Before and after acute exercise (about 30 minutes).
The cognitive-related biomarkers including brain derived neurotrophic factor
Change of metabonomics
时间窗: Before and after acute exercise (about 30 minutes).
The molecular response of exercise and environment through the measurement of peripheral blood
Change of oxyhemoglobin
时间窗: Before and after acute exercise (about 30 minutes).
Mearsurement of oxyhemoglobin using fNIRS
Change of cerebral blood flow
时间窗: Before and after acute exercise (about 30 minutes).
The blood flow of middle cerebral artery measured by ultrasonic doppler
次要结局
- Change of transcriptions(Three months (from baseline to the third month))
- Change of aerobic capacity(Three months (from baseline to the third month))
- Change of metabonomics(Three months (from baseline to the third month))
- Change of cognitive function(Three months (from baseline to the third month))
- Change of cerebral blood flow(Three months (from baseline to the third month))
- Change of biomarkers(Three months (from baseline to the third month))
- Change of oxyhemoglobin(Three months (from baseline to the third month))
研究者
Jianxiu Liu
Research staff
Tsinghua University