Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking
研究概览
简要总结
The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Are between the ages of 18-65 years
- •Have otherwise normal speech, language, hearing and cognition
- •Speak English as their primary language
- •Currently stutter
排除标准
- •Have serious medical or neurological conditions (e.g., stroke, traumatic brain injury, Parkinson's disease, etc.)
- •Have had a closed head injury (e.g., concussion)
- •Have a reading disorder (e.g., dyslexia)
- •Have hearing loss
- •Have metal or electronic implants (e.g., cochlear implants, pacemakers, etc.)
- •Are currently pregnant
研究组 & 干预措施
Stutter group
Participants that stutter
干预措施: Speech Production During functional magnetic resonance imaging (MRI) (Behavioral)
结局指标
主要结局
Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking
时间窗: During the speech task (5 runs, 8 minutes each) distributed across MRI Visits 1-6, up to 12 months from enrollment.
The Blood-oxygen-level-dependent (BOLD) signal reflects changes in blood oxygenation levels that are associated with neural activity. It is measured using functional magnetic resonance imaging (fMRI) and reported in arbitrary units (a.u.). The BOLD response provides an indirect index of localized brain activity during task performance, with increased signal indicating greater activation in a given brain region relative to baseline or a comparison condition. In this study, BOLD signal differences will be compared within participants across two speech production tasks: (1) stuttered speech and (2) non-stuttered speech. Each participant will complete the speech task on several of the MRI visits, which varies per participant (total amount of time spent will be the same across participants).
Blood-Oxygen-Level-Dependent (BOLD) signal change during speaking
时间窗: During the speech task (5 runs, 8 minutes each) distributed across MRI Visits 1-6, up to 12 months from enrollment.
The Blood-oxygen-level-dependent (BOLD) signal reflects changes in blood oxygenation levels that are associated with neural activity. It is measured using functional magnetic resonance imaging (fMRI) and reported in arbitrary units (a.u.). The BOLD response provides an indirect index of localized brain activity during task performance, with increased signal indicating greater activation in a given brain region relative to baseline or a comparison condition. In this study, BOLD signal differences will be compared within participants across two speech production tasks: (1) stuttered speech and (2) non-stuttered speech. Each participant will complete the speech task on several of the MRI visits, which varies per participant (total amount of time spent will be the same across participants).
次要结局
未报告次要终点
研究者
Soo-Eun Chang
Associate Professor of Psychiatry
University of Michigan