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临床试验/NCT02080741
NCT02080741终止不适用

Study in Leucocytes From Patients With Type 1 and Type 2 Diabetes Genetic Markers of Inflammation and Oxidative Stress (TÉLOMÈRES/ CANDIDATE GENES) According to the Type A or Type B Behavior Profile

Centre Hospitalier Universitaire Dijon1 个研究点 分布在 1 个国家目标入组 57 人开始时间: 2014年9月23日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
终止
入组人数
57
试验地点
1
主要终点
Telomere length

研究概览

简要总结

This study will include 100 patients with Type 1 and Type 2 diabetes, split into 2 groups of 50 patients according to their behaviour type, and their adaptation to different factors of stress encountered in their lives:

  • the first group will consist of patients with a characteristic Type A behaviour profile, that is to say patients with a "proactive, impatient" behaviour pattern
  • the second group will consist of patients with a characteristic Type B behaviour profile that is to say patients with a "calm, slow" behaviour pattern The objective is to know if the different behaviour patterns are associated with distinct biological markers likely to influence the evolution of the diabetes.

Participation in this study will be approximately 1h30, patients will participate ONCE ONLY:

  1. they will answer simple questions about their disease and then complete 3 questionnaires each with 14 items.
  2. they will meet a clinical psychologist for an interview lasting approximately 45 minutes recorded on an audio recorder. The consultation will be used to seek links between the psyche and the disease.
  3. they will provide one blood sample of 12 ml (equivalent to a soup spoon) drawn in the morning.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who have provided written informed consent
  • Patients with type 1 or type 2 diabetes
  • Patient admitted for a consultation, as out or in-patients to the Endocrinology-Diabetology-Metabolic diseases department of Dijon CHU
  • Patient > 18 years
  • Patient with either a characteristic Type A behaviour profile (Bortner > 210), or a characteristic Type B behaviour profile (Bortner<154)

排除标准

  • Persons not covered by national health insurance
  • Adults under guardianship or wards of court or not intellectually independent
  • Patients without diabetes
  • Patients with a mixed A/B behaviour profile (154< Bortner score <210)
  • Pregnant or breast-feeding women

研究组 & 干预措施

Type A behaviour profile

Other

干预措施: Blood sample of 12 ml (Other)

Type B behaviour profile

Other

干预措施: Blood sample of 12 ml (Other)

结局指标

主要结局

Telomere length

时间窗: Baselines

次要结局

  • Level of expression of candidate genes(Baselines)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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