Visual Mode Switching in Color Perception
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Change in EEG activity
研究概览
简要总结
Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.
详细描述
All participants will wear tinted lenses for 1 hour at a time, 5 times per day. Perception (behavior) and neural function (with functional MRI and EEG) before and after this experience will be measured. In the neural measurements, activity will be recorded while participants view stripes of many different colors both with the lenses on and off. In the perceptual measurements, participants will adjust the color of a small patch to appear neutral, neither red nor green. Behavior will be measured in a variety of conditions to test different hypotheses about the origins of the mode-switching effects. These include: 1) surrounding the patch with different colors, 2) preceding the presentation of the patch with presentation of different colors, 3) presenting the tests in a red-illuminated room, 4) presenting the tests in a completely darkened room, and 5) using a head-mount-display (virtual reality goggles) to present simulated lenses that gradually change in strength.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal or corrected to normal vision by contact lenses
- •No known visual disorders
- •Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)
排除标准
- •Abnormal color vision
研究组 & 干预措施
Color Contrast
Test patch is surrounded spatially by different colors
干预措施: Mode Switching Training (Behavioral)
Color Adaptation
Test patch is surrounded temporally (preceded) by different colors
干预措施: Mode Switching Training (Behavioral)
Neuroimaging
Functional MRI and Electroencephelography data are acquired for multiple test colors
干预措施: Mode Switching Training (Behavioral)
Red Room
Participants are tested in a red-illuminated room
干预措施: Mode Switching Training (Behavioral)
Dark Room
Participants are tested in a completely darkened room
干预措施: Mode Switching Training (Behavioral)
Gradual Change
Participants view a gradual change in tint, presented on a head-mounted display
干预措施: Mode Switching Training (Behavioral)
结局指标
主要结局
Change in EEG activity
时间窗: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Neural activity will be measured with electroencephelography using standard techniques and will be reported as voltage changes over time for each electrode in a standard configuration.
Change in BOLD functional MRI activity
时间窗: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Neural activation will be measured with functional MRI which will be used to measure BOLD activity with standard methods, and reported as percent change from rest, a standard measure, for each voxel in the brain.
Change in unique yellow settings
时间窗: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
This is a standard psychophysical measure referenced in 100s of papers. Participants adjust a patch of color until it appears neither red nor green and this color is reported in standard colorimetric coordinates (e.g. CIE).
次要结局
未报告次要终点