Prospective COVID-19 Cohort Study to Assess the Epidemiology, Transmission and Control of SARS-CoV-2 in the Dominican Republic
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,043
- 试验地点
- 1
- 主要终点
- Hand hygiene practices
研究概览
简要总结
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health facilities and (ii) a nationally representative cross-sectional community-based serological survey of approximately 7,000 healthy adults and children targeting SARS-CoV-2 and other AFI pathogens to be conducted between April and June 2021. This linked study will establish a nested cohort of 2,000 participants enrolled in the national serological survey and prospectively monitor them for COVID-19 symptoms, conduct serial serological testing, implement molecular surveillance for SARS-CoV-2 and sequencing for variants of concern, implement and evaluate WASH mitigation measures, and monitor uptake and perceptions of COVID-19 vaccines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Previously enrolled in a linked national community-based seroepidemiological study in the Dominican Republic
- •Agreed and consented to be recontacted to participate in additional research studies at the time of enrollment in #1
- •≥2 years of age
- •Agree to participate
排除标准
- •Ward of the State
结局指标
主要结局
Hand hygiene practices
时间窗: 1 year
The average daily frequency of study participant hand hygiene events over the previous seven days will be assessed using standardized survey questionnaires at 0-, 3-, 6-, 9-, and 12-months.
次要结局
- SARS-Cov-2 seroconversion(1 year)
- Acceptability of hand hygiene technology(1 year)
研究者
Eric J. Nilles, M.D.,M.S.C.
Principal Investigator
Brigham and Women's Hospital