Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Free (unbound) cloxacillin concentration
研究概览
简要总结
Cloxacillin is the first-line choice for the treatment of severe infections caused by the bacterium Staphylococcus aureus in Sweden. Over the past year, cloxacillin is increasingly administred through continuous infusion. In this study, the free (unbound) concentration of cloxacillin when administered as a continuous infusion will be measured to ensure that the free concentration is neither too high nor too low. A PK/PD model will be developed to predict which dosage of cloxacillin is appropriate for an individual based on age, gender, kidney function, and serum-protein level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Treating physician has decided to start continuous infusion of cloxacillin
排除标准
- •Unwilling or unable to provide written informed consent
研究组 & 干预措施
Treatment with cloxacillin as continuous infusion via elastomeric pump
Additional monitoring procedures performed: blood samples drawn before, after 4h, after 24h, and after 48h of continuous infusion of cloxacillin.
干预措施: Unbound cloxacillin concentration (Diagnostic Test)
结局指标
主要结局
Free (unbound) cloxacillin concentration
时间窗: From enrollment to end of follow up at 48 hours
次要结局
未报告次要终点
研究者
Emeli Månsson
Principal Investigator
Region Västmanland