Heat Waves in the Elderly: Reducing Thermal and Cardiovascular Consequences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 59
- 试验地点
- 2
- 主要终点
- Change in Core Body Temperature
研究概览
简要总结
The purpose of this study is to assess the cardiovascular responses of the elderly to heat wave conditions
详细描述
Heat waves are lethal and cause a disproportionate number of deaths in the elderly relative to any other age group. It is important to note that such deaths are primarily cardiovascular, not hyperthermia itself, in origin. Nevertheless, we know relatively little about the effects of aging on cardiovascular function during actual heat wave-like conditions. The central hypothesis of this work is that the elderly exhibit greater cardiovascular stress during heat wave conditions. Aim 1 will test the hypothesis that recognized impairments in thermoregulatory capacity in the elderly will culminate in heightened cardiovascular stress during prolonged exposure to heat wave conditions. Comprehensive cardiovascular and thermal responses in the elderly, relative to younger adults, will be evaluated during exposure to two prolonged heat wave conditions: hot and humid (replicating the 1995 Chicago heat wave) and very hot and dry (replicating the 2018 Los Angeles heat wave). The expected outcome from this body of work will re-shape our understanding of the consequences of aging on cardiovascular function during heat waves
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male and female individuals
- •18-35 years or 65+ years of age
- •Free of any underlying moderate to serious medical conditions
排除标准
- •Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.
- •Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.
- •Abnormalities detected on routine screening.
- •Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
- •Current smokers, as well as individuals who regularly smoked within the past 3 years.
- •Body mass index of greater than 30 kg/m^2
- •Pregnant individuals
结局指标
主要结局
Change in Core Body Temperature
时间窗: Prior to and after the 3-hour simulated heat wave exposure.
Core body temperature will be measured via a telemetric pill or rectal temperature probe.
Change in Peak Mitral Annular Systolic Velocity (S')
时间窗: Prior to, during, and after each simulated heat wave exposure; approximately 20 min each
Change in peak mitral annular systolic velocity was measured by tissue doppler imaging.
次要结局
- Ending Skin Temperature(At the end of the 3-hour simulated heat wave exposure.)
- Ending Heart Rate(At the end of the 3-hour simulated heat wave exposure.)
- Ending Mean Arterial Pressure(At the end of the 3-hour simulated heat wave exposure.)
- Change in Cardiac Output(Prior to and after the 3-hour simulated heat wave exposure.)
研究者
Craig Crandall
Professor of Medicine
University of Texas Southwestern Medical Center