Feasibility Evaluation - Blood Glucose Level Monitoring by Microwave Metamaterial Sensor in Blood Samples.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Blood sample relative permittivity
研究概览
简要总结
The goal of this clinical trial is to test microwave metamaterial glucose sensor on blood samples. It means to compare the results of glucose values obtained by microwave metamaterial sensor and by standard biochemical analyzer.
详细描述
Participants will include physiological and pathological populations. Participants donate approximately 5 ml of blood sample. Three sample tubes will be collected from ten adult participants. In the first test tube, the blood glucose content will be determined by a validated biochemical analyzer (Roche, Switzerland). In the remaining volume of the blood sample, the dielectric parameters (relative permittivity and conductivity) will be estimated using a coaxial probe (Keysight, USA). Microwave metamaterial sensors with 5, 7 and 9 unit cells will be loaded with blood samples and the specific scattering matrices will be obtained using a vector network analyzer. The main monitored outcome measure will be the phase of parameter S21.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •blood glucose can be measured with standard biochemical analyzer
排除标准
- •minimum age limit 18 years
研究组 & 干预措施
Blood sample donator
The participant donates approximately 5 ml of blood sample.
干预措施: In vitro full blood diagnostic test. (Diagnostic Test)
结局指标
主要结局
Blood sample relative permittivity
时间窗: When blood sample is presented into the co-axial probe container within 24 hours from blood collection.
The relative permittivity (-) of the blood samples will be measured using a coaxial probe.
Phase shift of scattering parameter S21
时间窗: When blood sample is filled into sensor chamber within 24 hours from blood collection.
The proposed microwave sensor uses a section of planar metamaterial transmission line operating at GHz frequencies. The speed of electromagnetic wave propagation through the sample is affected by the concentration of glucose. The delay can be expressed in degrees (°) as the phase of the complex S21 parameter.
Blood sample specific electrical conductivity
时间窗: When blood sample is presented into the co-axial probe container within 24 hours from blood collection.
The specific electrical conductivity (S/m) of the blood samples will be measured using a coaxial probe.
Blood glucose concentration
时间窗: When blood sample is processed in biochemical analyzer within 24 hours from blood collection.
Molar mass of glucose dissolved in liquid blood sample expressed as molar concentration (mmol/l).
次要结局
- Mathematical model of blood glucose dependence on blood dielectric parameters(After primary data acqiusition.)
- Sensor sensitivity(After primary data acqiusition.)