Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol: a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Time to open eyes under investigator's command
研究概览
简要总结
Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status (ASA PS) I-II
- •Age 20 - 60 years male and female
- •Elective schedule with minor surgery under general anesthesia
排除标准
- •Body mass index (BMI) >= 30 (kg/m2)
- •Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
- •Patient with medication affecting on this study
- •Patient with general anesthesia history within one month
结局指标
主要结局
Time to open eyes under investigator's command
时间窗: From cessation of propofol infusion to patient's eye opening (seconds)
After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.
次要结局
- Time to extubation(From cessation of propofol infusion to extubation (sec))
- Time to breath spontaneously(From cessation of propofol infusion to patient's spontaneous breathing (sec))
- Time to open mouth under investigator's command(From cessation of propofol infusion to patient's mouth opening (seconds))
- Change of bispectral index (BIS)(From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded.)
研究者
Junyong In, MD
Associate professor
DongGuk University