Reduced GLP-1 Response is Associated With Prediabetes in Women With Adverse Metabolic Phenotype of PCOS Independently of BMI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- The main outcome was difference in fasting and after load GLP1 levels between two groups
研究概览
简要总结
Women with PCOS are more prone to obesity which exacerbates insulin resistance, the abdominal fat disposition and metabolic risk of these patients. With development of obesity these women have high conversion rate from normal glucose tolerance to impaired glucose tolerance and in turn to type 2 diabetes.
Glucagon-like peptide 1 (GLP-1) is involved in body weight maintenance. Beside energy balance it is also involved in glucose homeostasis. Functional deficit in GLP-1 facilitates obesity. We investigated the link between the concentration of incretin hormones and glucose homeostasis, metabolic complications and the distribution of body composition in obese women with PCOS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18 years old to menopause
- •polycystic ovary sindrome (NICHD criteria)
- •BMI of 30 kg/m2 or higher
排除标准
- •type 1 or type 2 diabetes mellitus
- •Cushing's syndrome or congenital (non-classic) adrenal hyperplasia
- •personal or family history of MEN 2
- •the use of medications known or suspected to affect reproductive or metabolic functions
- •the use of statins within 90 days prior to study entery
研究组 & 干预措施
NGT
NGT - normal glucose tolerance. Women with PCOS and normal glucose tolerance
干预措施: oral glucose tolerance test (Diagnostic Test)
IGH
IGH - impaired glucose homeostasis Women with PCOS and impaired glucose homeostasis - that means impaired fasting glucose or impaired glucose tolerance.
干预措施: oral glucose tolerance test (Diagnostic Test)
结局指标
主要结局
The main outcome was difference in fasting and after load GLP1 levels between two groups
时间窗: 3h
Patient GLP1 levels were measured at base point and in 120 min of 75-g OGTT. GLP1 levels were compared between groups
次要结局
- The secondary outcome was to evaluate the between group difference in beta cell function, and visceral adipose tissue.(3h)
研究者
Andrej Janez
MD PhD
University Medical Centre Ljubljana