Effects of an Eight-Week Whole-Body Electromyostimulation and Diet Program on Body Composition, Cardiometabolic Markers, and the Myokines Irisin and Betatrophin in Women With Obesity: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Body Weight
研究概览
简要总结
This randomized controlled trial investigated the effects of an 8-week whole-body electromyostimulation (WB-EMS) combined with a hypocaloric diet on body composition, cardiometabolic markers, and serum levels of the myokines irisin and betatrophin (ANGPTL8) in women with obesity. Participants were randomly assigned to either a diet-only group or a diet plus WB-EMS group. WB-EMS sessions were conducted twice weekly (20-25 minutes per session) over 8 weeks. The primary outcomes included BMI, body fat percentage, lean body mass, fasting blood glucose, insulin, HOMA-IR, HbA1c, lipid profile, CRP, and serum irisin and betatrophin concentrations. The study aimed to evaluate whether WB-EMS adds metabolic and myokine-related benefits beyond those achieved by dietary restriction alone in obese women.
详细描述
This study was a randomized controlled trial (RCT) designed to investigate the effects of an 8-week whole-body electromyostimulation (WB-EMS) combined with a hypocaloric diet on body composition, cardiometabolic markers, and serum levels of the myokines irisin and betatrophin (ANGPTL8) in women with obesity.
Participants were randomly assigned to one of two groups: (1) Diet-only group (control): received a hypocaloric diet prescription without exercise training; (2) WB-EMS + Diet group (intervention): received the same hypocaloric diet plus WB-EMS training sessions conducted twice weekly (20-25 minutes per session) over 8 weeks.
Body composition assessments included body weight, BMI, body fat percentage, fat mass, fat-free mass, and waist circumference, measured using multifrequency bioelectrical impedance analysis (InBody 270). Cardiometabolic markers assessed included fasting blood glucose, serum insulin, HOMA-IR, HbA1c, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, and C-reactive protein (CRP). Serum irisin and betatrophin concentrations were measured at baseline and post-intervention using ELISA.
The primary aim was to evaluate whether WB-EMS combined with dietary restriction provides additional metabolic and myokine-related benefits beyond those achieved by dietary restriction alone in obese women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Adult women aged 18-65 years
- •BMI >= 30 kg/m2 (obesity)
- •Sedentary lifestyle (no regular physical activity for the past 6 months)
- •Willingness to participate and provide written informed consent
排除标准
- •Pregnancy or breastfeeding
- •Cardiovascular disease, neurological disorders, or implanted pacemaker/defibrillator
- •Active cancer or ongoing chemotherapy/radiotherapy
- •Use of medications affecting body weight or metabolic parameters
- •Prior WB-EMS training experience
- •Skin conditions contraindicating electrode use
结局指标
主要结局
Body Weight
时间窗: 8 weeks (baseline to post-intervention)
Changes in body weight (kg) measured by multifrequency bioelectrical impedance analyser (InBody 270) from baseline to post-intervention (8 weeks).
Body Mass Index (BMI)
时间窗: 8 weeks (baseline to post-intervention)
Changes in body mass index (BMI, kg/m²) measured by multifrequency bioelectrical impedance analyser (InBody 270) from baseline to post-intervention (8 weeks).
Body Fat Percentage
时间窗: 8 weeks (baseline to post-intervention)
Changes in body fat percentage (%) measured by multifrequency bioelectrical impedance analyser (InBody 270) from baseline to post-intervention (8 weeks).
Fat Mass
时间窗: 8 weeks (baseline to post-intervention)
Changes in fat mass (kg) measured by multifrequency bioelectrical impedance analyser (InBody 270) from baseline to post-intervention (8 weeks).
Fat-Free Mass (Lean Body Mass)
时间窗: 8 weeks (baseline to post-intervention)
Changes in fat-free mass / lean body mass (kg) measured by multifrequency bioelectrical impedance analyser (InBody 270) from baseline to post-intervention (8 weeks).
Waist Circumference
时间窗: 8 weeks (baseline to post-intervention)
Changes in waist circumference (cm) measured by standard anthropometric tape from baseline to post-intervention (8 weeks).
次要结局
- Fasting Blood Glucose (FBG)(8 weeks (baseline to post-intervention))
- Serum Insulin(8 weeks (baseline to post-intervention))
- HOMA-IR (Insulin Resistance)(8 weeks (baseline to post-intervention))
- Glycated Haemoglobin (HbA1c)(8 weeks (baseline to post-intervention))
- Total Cholesterol (TC)(8 weeks (baseline to post-intervention))
- Triglycerides (TG)(8 weeks (baseline to post-intervention))
- LDL Cholesterol (LDL-C)(8 weeks (baseline to post-intervention))
- HDL Cholesterol (HDL-C)(8 weeks (baseline to post-intervention))
- C-Reactive Protein (CRP)(8 weeks (baseline to post-intervention))
- Serum Irisin(8 weeks (baseline to post-intervention))
- Serum Betatrophin (ANGPTL8)(8 weeks (baseline to post-intervention))
- Systolic Blood Pressure(8 weeks (baseline to post-intervention))
- Diastolic Blood Pressure(8 weeks (baseline to post-intervention))
研究者
Murat Açık
Assistant Professor
Firat University