Effects and Importance of Epinephrine/Adrenalin Deficiency in CAH
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- epinephrine level
研究概览
简要总结
Individuals with CAH produce lower levels of epinephrine (adrenalin) than controls. This can be correlated to the CYP21A2 genotype and is most pronounced in the classic forms. Individuals with CAH have an increased risk of developing hypoglycemia because both cortisol and epinephrine are important counter regulatory hormones. Stress dosing is essential in situations of increased physical stress such as infections with fever for example.
Glucocorticoid treatment and stress dosing cannot compensate fully during physical stress neither for the reaction to psychological stress. This may render various types of difficulties in the individual's life.
We aim to investigate if the deficient epinephrine production can be confirmed and if it is related to the increased level of anxiety and vulnerability to stress that we observe in the patients.
Specific aims of the study:
- Analyse the epinephrine/adrenalin production in patients with CAH using measurements of epinephrine and metanephrine in blood, during an exercise test
- Assess stress vulnerability and anxiety using validated questionnaires
- Correlate the results to severity of disease, CYP21A2 genotype
- Investigate if psychological and somatic stress symptoms are related to the epinephrine production capacity.
详细描述
After written informed consent study subjects, patients and controls, are invited to fill in a web based survey with the validated questionnaires. A link to the survey, expected to take 30 - 60 minutes to complete, is mailed to to the subjects . A subgroup of study subjects are invited to perform an ergo-spirometri test followed by the exercise test at the hospital. They are asked not to eat for 6 hours or drink any coffe during the day before the test. A venous catheter is used for blood sampling during the exercise. ECG, an orthostatic blood pressure test and a the ergo-spirometry test are performed before the subject is asked to do the exercise test, a cycling maximum test. Blood glucose, lactate, are followed every 4 minutes. Adrenal androgens, cortisol, insulin and methoxy-catecholamine are measured before and when the subject has reached maximum effort load and the test is ended.
The physical capacity, orthostatic blood pressure and the blood test results are related to the severity of CAH and to the maximum level of methoxy-cathecholamine produced by each individual. In the larger group of individuals, not taking part in the exercise test but completing the survey the genotype is correlated to the questionnaire results.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •CAH due to 21-hydroxylase deficiency,
排除标准
- •Cardiovascular disease
结局指标
主要结局
epinephrine level
时间窗: 2022 December 31
Measured methoxy-catecholamine at maximum exercise test, cycling test.
次要结局
- Liebowitz anxiety scale(2022 December 31)
- Hospital Anxiety Depression Scale(2022 December 31)
- Mental Fatigue scale(2022 December 31)
- Karolinska Exhaustion disorder scale(2022 December 31)
- sleep questionnaire(2022 December 31)
研究者
Anna Jung Nordenstrom
Adj Professor, Senior Consultant
Region Stockholm