Exercise Dose and Insulin Sensitivity in Obese Children
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 222
- 试验地点
- 2
- 主要终点
- Insulin area under the curve (oral glucose tolerance test)
研究概览
简要总结
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on risk for type 2 diabetes, fatness, fitness, blood cholesterol levels, and other cardiovascular risk factors in overweight elementary schoolchildren.
The hypothesis is that the more exercise a child does, the more benefit he or she will gain in reducing the risk of diabetes and other cardiovascular diseases.
An ancillary study examined effects on cognition and achievement.
详细描述
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on insulin response to the oral glucose tolerance test, body composition, fitness, lipid profile, inflammation and other metabolic syndrome components in overweight elementary schoolchildren.
Blinded psychological assessments of cognition and achievement were obtained.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 7 Years 至 11 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight, sedentary children
- •Black or white race
- •Attending specific schools in Augusta, GA area from which this study is recruiting
排除标准
- •Unable to participate in testing or vigorous exercise program
- •Taking medication that would affect study results
- •Sibling enrolled in project
结局指标
主要结局
Insulin area under the curve (oral glucose tolerance test)
时间窗: 10-15 weeks
Body composition (% body fat, visceral fat)
时间窗: 10-15 weeks
Aerobic fitness
时间窗: 10-15 weeks
Cognition (Executive function)
时间窗: 10-15 weeks
次要结局
- Glucose (oral glucose tolerance test)(10-15 weeks)
- Inflammation (C-reactive protein, fibrinogen)(10-15 weeks)
- Lipid profile(10-15 weeks)
- Blood pressure(10-15 weeks)
- Academic achievement(10-15 weeks)