NCT01321476撤回不适用
Contribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Demonstrated Plaques
研究概览
简要总结
This study will use excess tissue from endoscopic or surgical procedures to examine the elements of plaque that are found in the carotid walls of patients who have a type of heart and blood vessel disease called atherosclerosis. Tissue will be collected from patients undergoing carotid procedures as well as patients undergoing liver and/or intestinal biopsies. This lab study will examine the different types of proteins that play a role in developing heart plaque.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years
- •Scheduled for a clinically indicated, standard-of-care carotid endarterectomy (CEA) OR scheduled for a clinically indicated, standard-of- care surgical, laparoscopic or endoscopic intestinal biopsy or excision OR scheduled for a clinically indicated, standard-of-care surgical, laparoscopic or endoscopic liver biopsy or partial resection/excision
- •Ability and willingness to consent and Authorization for use of PHI
排除标准
- •Age ≤18 years
- •Inability or unwillingness to consent and Authorization for use of PHI
- •FOR CAROTID PATIENTS - history of carotid trauma, that is determined by the Principal Investigator to significantly have changed the carotid tissue structure
- •FOR CAROTID PATIENTS - history of middle- or large-vessel vasculitis, that is determined by the Principal Investigator to significantly have changed the carotid tissue structure
结局指标
主要结局
Demonstrated Plaques
时间窗: up to 30 months
Presence of both liver and intestinally derived lipoprotein particles demonstrated in human atherosclerotic plaques.
次要结局
未报告次要终点
研究者
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