NL-OMON54874招募中不适用
Effects of COVID-19-infection on movement and tissue characteristics of the diaphragm visualized by magnetic resonance imaging: a proof-of-concept study - Diaphragm MRI
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational invasive
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Invasive mechanical ventilation > 72 hours during current hospital admission
- •(only patients)
- •Discharged from the ICU <= 14 days ago (only patients)
- •Admitted for COVID-19-infection (n = 10)
- •Currently negative COVID-19 PCR test (only previously infected subjects)
- •Age 50-70 years (only healthy volunteers)
- •Signed informed consent
- •Age >= 18 years (only patients)
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Known history of:
- •o Diaphragmatic injury or weakness
- •o COPD (GOLD IV)
- •o Neuromuscular disease (including pathology of the n. phrenicus)
- •o Connective tissue disease
- •o Chronic use of corticosteroids (>7.5 mg/day for at least 3 months before
- •hospital admission)
- •o >10% weight loss within last 6 months (before hospital admission)
- •o COVID-19-infection, confirmed with positive test (except for subset of
- •infected patients)
- •Known pregnancy
- •Contraindications for MRI
- •o Electrical/metallic implants
- •o Claustrophobia
- •Hierarchical relation with one of the collaborating investigators
- •Incapacitation
- •Contraindications for the use of a Gadolinium based contrast agent for MRI
- •o eGFR < 30 ml/min/1.73m2
- •o Known history of allergic reactions to a MRI contrast medium
- •o Known history of atopy
- •o Unstable Asthma
- •Additional exclusion criteria for the control group are:
- •History of mechanical ventilation > 24 hours
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