Quantitative Sensory Testing, Blink Reflex and Nociceptive Flexion Reflex in the Pathophysiology of Headache
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- modulation of pain threshold by fremanezumab
研究概览
简要总结
The aim of this study is to compare central and peripheric sensitization in headache patients at Baseline (T0) and 1 month after (T1) a treatment with an anti-CGRP (Fremanezumab-Ajovy).
详细描述
20 patients and 20 healthy subjects will be enrolled. The headache patients will be recruited just before starting their treatment and 1 month after (corresponding to the efficacy peak). Hot and cold stimulations will be delivered with the ATS probe from the Medoc Pathway on the forehead and on the hand (palmar face) to determine painful threshold to warm/cold stimuli. A blink reflex will be generated with a concentric electrode placed over the eyebrow and with active/earth electrodes linked to the EMG machine for the recording. For the nociceptive flexion reflex, a cutaneous stimulation will be applied on the arm and the response recorded on the corresponding muscles.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with headache which are about to receive a treatment with fremanezumab
排除标准
- •medication changes 1 month prior to the test
- •neuropathy
- •acute or chronic pain
- •medications having effects on the central nervous system
- •other disease
结局指标
主要结局
modulation of pain threshold by fremanezumab
时间窗: one year
Blink reflex and nociceptive flexion reflex usig EMG Viking Viasys.
次要结局
未报告次要终点
研究者
Manise Maite
Doctor in Medical Sciences
University of Liege