NCT02539745已完成不适用
Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma
Lv Yingjuan1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2013年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Serum levels of 1a, 25-Dihydroxyvitamin D3
研究概览
简要总结
This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •intraocular pressure greater than 22 mmHg with two or more medications
- •wide anterior chamber angle
- •glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect)
- •visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
排除标准
- •the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma
- •high myopia
- •macular degeneration
- •other ocular diseases
- •a known history of systemic diseases and administration of vitamin D3 or other analog
结局指标
主要结局
Serum levels of 1a, 25-Dihydroxyvitamin D3
时间窗: 1 day visit
次要结局
- gene polymorphisms of vitamin D receptor(1 day visit)
研究者
Lv Yingjuan
department of ophthamology
Tianjin Medical University Eye Hospital
研究点 (1)
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