Multicenter Randomized CLinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 500
研究概览
简要总结
2014 Protocol article in http://www.ncbi.nlm.nih.gov/pubmed/25179366 protocol 2015 Results article in http://www.ncbi.nlm.nih.gov/pubmed/25517348 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/26903582 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27302238 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27421546 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27491736 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27601379 results 2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27827328 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28379802 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28351963 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28389610 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28531910 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28432266 results 2017 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28436305 results 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28404769 results 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/29321337 results 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/28799861 results 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/29040040 results 2018 Results article in http://www.ncbi.nlm.nih.gov/pubmed/29365017 results 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30571406 results 2019 Results article in http://www.ncbi.nlm.nih.gov/pubmed/30297537 results 2019 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/31825939 post hoc analysis (added 12/12/2019) 2021 Abstract results in https://pubmed.ncbi.nlm.nih.gov/34645287/ Economic evaluation (added 15/10/2021) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35674042/ retrospective analysis (added 09/06/2022) 2021 Abstract results in https://doi.org/10.1177/23969873211034932 Results abstract European Stroke Organisation Conference 2021 (added 29/03/2023) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/38102770/ Multivessel occlusions (MVO) (added 18/12/2023)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. A clinical diagnosis of acute stroke, with a deficit on the National Institutes of Health (NIH) stroke scale of 2 points or more
- •2. Computerised tomography (CT) or magnetic resonance imaging (MRI) scan ruling out intracranial hemorrhage
- •3. Intracranial arterial occlusion of the distal intracranial carotid artery or middle (M1/M2) or anterior (A1/A2) cerebral artery, demonstrated with Computed Tomography Angiography (CTA), magnetic resonance angiography (MRA), Digital subtraction angiography (DSA) or transcranial Doppler/duplex (TCD)
- •4. The possibility to start treatment within 6 hours from onset
- •5. Informed consent given
- •6. Age 18 or over
排除标准
- •1. Arterial blood pressure > 185/110 mmHg
- •2. Blood glucose < 2.7 or > 22.2 mmol/L
- •3. Intravenous treatment with thrombolytic therapy in a dose exceeding 0.9 mg/kg alteplase or 90 mg
- •4. Intravenous treatment with thrombolytic therapy despite contra-indications, i.e. major surgery, gastrointestinal bleeding or urinary tract bleeding within the previous 2 weeks, or arterial puncture at a non-compressible site within the previous 7 days
- •For Intended mechanical thrombectomy:
- •Laboratory evidence of coagulation abnormalities, i.e. platelet count <40 x 109/L, activated partial thromboplastin time (APTT)>50 sec or International Normalised Ratio (INR) >3.0.
- •For intended intra-arterial thrombolysis:
- •1. Cerebral infarction in the distribution of the relevant occluded artery in the previous 6 weeks
- •2. History of intracerebral hemorrhage
- •3. Severe head injury (contusion) in the previous 4 weeks
- •4. Clinical or laboratory evidence of coagulation abnormalities, i.e. platelet count <90 x 109/L, APTT>50 sec or INR >1.7