Effects of Different Kinds, Different Doses of 5-HT3 Receptor Antagonists on Prevention of Hypotension After Spinal Anesthesia
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- prevention of hypotension by calcaulation the gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 minutes after spinal anesthesia.
研究概览
简要总结
The purpose of this study is to estimate effects of different kinds, different dose of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing spinal anesthesia
排除标准
- •hypersensitivity on 5-HT3 receptor antagonists hypertension cardiovascular disease intake of selective serotonin reuptake inhibitor
研究组 & 干预措施
ramosetron 0.3 mg
preparation of ramosetron 0.3 mg
干预措施: ramosetron (Drug)
ondansetron 8 mg
preparation of ondansetron 8mg
干预措施: ondansetron (Drug)
ondansetron 4 mg
preparation of ondansetron 4mg
干预措施: ondansetron (Drug)
non 5-HT3 receptor antagonist
preparation of normal saline 5 ml
干预措施: placebo (Drug)
结局指标
主要结局
prevention of hypotension by calcaulation the gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 minutes after spinal anesthesia.
时间窗: up to 30mins after spinal anesthesia
comparasion of significantly difference in the gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 minutes after spinal anesthesia.
次要结局
- prevention of hypotension bycalculation the gap baseline systolic and diastolic blood pressure and lowerst systolic and diastolic blood pressure(up to 30mins after spinal anesthesia)
研究者
Wonsik Ahn
Associate Professor
Seoul National University Hospital