Metabolic Characteristics of Plasma OxPLs in STEMI Patients and Its Value Analysis in Predicting MACEs Risk After PCI Surgery.
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Number of Participants with Treatment-Related Adverse Events as Assessed by CTCAE v5.0
研究概览
简要总结
The goal of this observational study is to investigate the structural composition and metabolic characteristics of OxPLs in STEMI patients. Explore OxPLs characteristic fingerprint biomarkers from different populations and analyze OxPLs fingerprint spectra. Based on the OxPLs fingerprint of STEMI patients, a machine learning classifier is used to establish an artificial intelligence assisted post PCI MACE risk prediction system, achieving the transformation of basic research into clinical application.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The patient meets the diagnostic criteria for STEMI (refer to the "Diagnosis and Treatment Guidelines for Acute ST Segment Elevation Myocardial Infarction (2021)")
- •Agree to perform direct PCI
- •The onset time is less than 12 hours and successfully undergoing emergency PCI treatment
- •After admission, all STEMI patients are routinely treated with antiplatelet aggregation, anticoagulation, lipid-lowering, and anti myocardial remodeling drugs.
排除标准
- •Previous history of myocardial infarction
- •Accompanied by other cardiovascular diseases, such as severe heart valve disease, severe heart failure, congenital heart disease, cardiomyopathy, etc
- •Merge with severe infection
- •Merge with severe anemia
- •Merge with severe liver and kidney dysfunction
- •Combined with malignant tumors
- •Accompanied by a history of autoimmune or hematological diseases
- •Recent history of severe trauma or surgery
- •Patients with incomplete clinical data
- •The patient does not agree to undergo data collection
研究组 & 干预措施
Healthy
Healthy people
CAD
Stable coronary heart disease patient
STEMI-M
Male patients with ST segment elevation myocardial infarction
STEMI-F
female patients with ST segment elevation myocardial infarction
结局指标
主要结局
Number of Participants with Treatment-Related Adverse Events as Assessed by CTCAE v5.0
时间窗: 12 months
次要结局
未报告次要终点