NCT02153281已完成不适用
Neuroimaging MAO-B in Medication Free and Treatment Resistant Major Depressive Disorder Using Novel MAO-B Tracer
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- MAO-B VT levels measured with PET in MDE secondary to MDD
研究概览
简要总结
The purpose of this study is to determine if monoamine oxidase B (MAO-B) total distribution volume (VT), after phenelzine treatment and if so to what extent.
详细描述
Subjects will receive a PET and MRI scan before and after treatment with phenelzine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-80 years of age
- •good physical health
- •Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of current major depressive episode (MDE)
- •DSM-IV diagnosis of major depressive disorder (MDD) verified by SCID for DSM-IV and a psychiatric consultation
- •greater than 17 on the 17 item HDRS (Hamilton Depression Rating Scale).
- •history of non-response to several different antidepressant classes
排除标准
- •herbal, drug or medication use (that affect CNS function)
- •suicide attempts
- •drug or medication use within eight weeks (+5 half lives of medication)
- •history of substance abuse or any neurotoxin use
- •history of psychotic symptoms
- •history of central nervous system (CNS) medical illness
- •current substance abuse
- •test positive on pregnancy test (for women)
研究组 & 干预措施
Phenelzine treatment
Experimental
Subjects will undergo a PET and MRI scan before and after the treatment.
干预措施: phenelzine treatment (Other)
结局指标
主要结局
MAO-B VT levels measured with PET in MDE secondary to MDD
时间窗: 8 weeks
次要结局
未报告次要终点
研究者
Jeff Meyer
Head Neurochemical Imaging in Mood Disorders
Centre for Addiction and Mental Health
研究点 (2)
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