The Association Between Anti-osteoporosis Medications and Lowered All Cause Mortality After Osteoporotic Fractures
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 216,155
- 试验地点
- 1
- 主要终点
- Number of deaths with and without bisphosphonates after hip or spine fracture surgery
研究概览
简要总结
Osteoporotic fracture is a common public-health problem in the whole world. Although postfracture usage of anti-osteoporosis medications, may reduce mortality, recent results have been inconsistent. The investigators aim to examine associations between osteoporosis medication and mortality in older adults and any type of fracture patients. The investigators also aim to discuss the pleiotropic effects of different types of anti-osteoporosis medications.
详细描述
Osteoporotic fracture has become a serious health and economic burden as life expectancy increases. In a WHO report, the burden of osteoporotic fractures in 2002 was 2.8 million disability-adjusted life years, which is more than that for hypertension and slightly less than that for diabetes mellitus or chronic obstructive pulmonary diseases. Many patients who have had a diagnosed fracture have never been diagnosed with osteoporosis, therefore, closing the gap in osteoporosis treatment is important. This situation is primarily due to the fact that osteoporosis symptoms are often not recognized until a fracture occurs. Osteoporotic fractures, especially those of the hip and vertebral, are associated with an increased risk of death. Early detection of high risk for osteoporotic fractures is important; however, post-fracture management, especially interventions intended to lower mortality, is an emerging public health issue in rapidly aging societies. The burden of osteoporotic fracture is higher than that of hypertension, however, osteoporosis is always given less attention than other chronic diseases by health professionals and the general population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Newly diagnosed osteoporosis and hip fracture are defined as a claim record from the NHIRD between 2009 and 2017.
排除标准
- •Patients with a diagnosis of osteoporosis or osteoporotic fractures in 2008 or before were excluded.
研究组 & 干预措施
Used osteoporosis medication
Patients who had used osteoporosis medication after osteoporotic fractures.
干预措施: Anti-osteoporosis medications (Drug)
Did not use osteoporosis medication
Patients who didn't use osteoporosis medication after osteoporotic fractures.
干预措施: Anti-osteoporosis medications (Drug)
结局指标
主要结局
Number of deaths with and without bisphosphonates after hip or spine fracture surgery
时间窗: 12 years
This is the number of participants who died during the time of observation from Taiwan's National Health Insurance Research Database.
Number of deaths with and without anti-osteoporotic therapy after hip fracture surgery
时间窗: 12 years
This is the number of participants who died during the time of observation from Taiwan's National Health Insurance Research Database.
Number of deaths with or without anti-osteoporosis therapy after hip or vertebral fracture surgery among older adults
时间窗: 12 years
This is the number of participants who died during the time of observation from Taiwan's National Health Insurance Research Database.
Number of deaths with different types of anti-osteoporosis treatments after post-fracture
时间窗: 12 years
This is the number of participants who died during the time of observation from Taiwan's National Health Insurance Research Database.
Number of deaths in five leading causes of death with and without anti-osteoporosis treatment after post-fracture
时间窗: 12 years
This is the number of participants who died during the time of observation from Taiwan's National Death Registry. The five leading causes are defined as the main five leading causes.
次要结局
未报告次要终点
研究者
Chih-Hsing Wu
Associate Professor
National Cheng-Kung University Hospital