NCT06967441招募中不适用
Respiratory Virus Infections in Hospitalized Patients With Acute Heart Failure Syndrome: A Prospective Multi-center Observational Study
Minjae Yoon3 个研究点 分布在 1 个国家目标入组 360 人开始时间: 2025年4月7日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 360
- 试验地点
- 3
- 主要终点
- Respiratory virus PCR detection rate
研究概览
简要总结
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.
The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult aged 19 years or older admitted to the cardiology department with acute heart failure
- •NT-proBNP >300 pg/mL
- •Clinician judgement of possible respiratory viral infection (fever >38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5 mg/dL)
- •Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons
排除标准
- •Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP >180mmHg or DBP >110mmHg), haemoglobin <7g/dL or AHF precipitated by medication non-adherence)
- •If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
- •If there is a clear other source of infection that can explain the fever
结局指标
主要结局
Respiratory virus PCR detection rate
时间窗: Within 3 days of admission
Respiratory virus PCR detection rate (especially RSV, influenza virus) in acute HF
次要结局
- Days of hospitalization(From admission to discharge during index hospitalization (upto 30 days))
- Rate of ICU care or ventilation(From admission to discharge during index hospitalization (upto 30 days))
- In hospital mortality(From admission to discharge during index hospitalization (upto 30 days))
- mortality(12 month)
- Rehospitalization(12month)
研究者
Minjae Yoon
Assistant professor
Seoul National University Bundang Hospital
研究点 (3)
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